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Artículo

Antifungal susceptibility profile and molecular identification of Cyp51C mutations in clinical and environmental isolates of Aspergillus flavus from Argentina

Hermida Alava, Katherine StefaniaIcon ; Brito Devoto, TomásIcon ; Sautua, Francisco; Gordó, Manuela; Scandiani, María Mercedes; Formento, Ángela Norma; Luque, Alicia Graciela; Carmona, Marcelo Anibal; Cuestas, María LujánIcon
Fecha de publicación: 01/2021
Editorial: Wiley Blackwell Publishing, Inc
Revista: Mycoses
ISSN: 0933-7407
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología Celular, Microbiología; Ecología; Epidemiología

Resumen

Background: The emergence of azole resistance in non-fumigatus Aspergillus strains is on the raise. Objectives: To study the susceptibility profiles and the molecular mechanisms of azole resistance of environmental and clinical strains of Aspergillus flavus from Argentina. Methods: Thirty-five A flavus isolates (18 from soybean seeds and chickpea seeds and 17 from the clinic) were analysed for amphotericin B and azole resistance using the standard microbroth dilution method according to CLSI M38-A2 guidelines. Sequencing analysis of the cyp51 genes was conducted in those isolates displaying high MICs values to itraconazole, voriconazole and/or posaconazole. Results: Among the environmental isolates, 33.3% of them showed high MIC values for at least one triazole whereas 23.5% of the clinical isolates displayed high MIC values for amphotericin B. Point mutations in the Cyp51C gene were recorded in most environmental isolates with non-wild-type MIC values. Conclusions: Susceptibility differences among environmental A flavus isolates might suggest the possibility of native resistance to certain triazole antifungals used in the clinic. To the best of our knowledge, this is the first report of antifungal screening of environmental strains of A flavus in soybean seeds and chickpea seeds from Argentina that showed increased resistance to voriconazole and itraconazole in comparison to clinical strains.
Palabras clave: ARGENTINA , ASPERGILLUS FLAVUS , CHICKPEA SEEDS , CYP51 C , ITRACONAZOLE , SOYBEAN SEEDS , TRIAZOLE RESISTANCE , VORICONAZOLE
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/151590
URL: https://onlinelibrary.wiley.com/doi/10.1111/myc.13193
DOI: http://dx.doi.org/10.1111/myc.13193
Colecciones
Articulos(IMPAM)
Articulos de INSTITUTO DE INVESTIGACIONES EN MICROBIOLOGIA Y PARASITOLOGIA MEDICA
Citación
Hermida Alava, Katherine Stefania; Brito Devoto, Tomás; Sautua, Francisco; Gordó, Manuela; Scandiani, María Mercedes; et al.; Antifungal susceptibility profile and molecular identification of Cyp51C mutations in clinical and environmental isolates of Aspergillus flavus from Argentina; Wiley Blackwell Publishing, Inc; Mycoses; 64; 1; 1-2021; 95-101
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