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dc.contributor.author
Galleano, Mónica Liliana
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dc.contributor.author
Pechanova, Olga
dc.contributor.author
Fraga, César Guillermo
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dc.date.available
2022-02-08T11:23:08Z
dc.date.issued
2010-07
dc.identifier.citation
Galleano, Mónica Liliana; Pechanova, Olga; Fraga, César Guillermo; Hypertension, nitric oxide, oxidants, and dietary plant polyphenols; Bentham Science Publishers; Current Pharmaceutical Biotechnology; 11; 8; 7-2010; 837-848
dc.identifier.issn
1389-2010
dc.identifier.uri
http://hdl.handle.net/11336/151548
dc.description.abstract
Fruits and vegetables are key foods whose high ingestion is associated with the improvement of numerous pathological conditions, including hypertension. Such health promoting actions have been increasingly ascribed to the antioxidant characteristics of different polyphenols in fruits and vegetables. Consequently, based on this assumption, many beverages and foods rich in polyphenols, grape, tea, cocoa, and soy products and many of their chemical constituents purified, are being studied both, as antioxidants and antihypertensive agents. This paper reviews the current evidence linking high polyphenol consumption with reductions in blood pressure. Basic chemical aspects of flavanols, flavonols, isoflavones and stilbenes, as possible responsible for the observed effects of those foods on blood pressure are included. Human intervention studies by using grapes and wine, cocoa and chocolate, black and green tea, soy products, and purified compounds ((+)-catequin, quercetin, (-)-epigallocatechin gallate) are summarized. The discussed hypothesis, strongly supported by experimental data in animals, is that by regulating nitric oxide bioavailability, polyphenols present in fruits and vegetables affect endothelial function and as a consequence, blood pressure. Even when data are not definitive and many questions remain open, the whole evidence is encouraging to start considering diets that can provide benefits to hypertensive subjects, and those benefits will be more significant in people that do not have controlled his/her elevated blood pressure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTIOXIDANTS
dc.subject
HYPERTENSION
dc.subject
NITRIC OXIDE
dc.subject
NOS
dc.subject
NOX
dc.subject
POLYPHENOLS
dc.subject
RENIN-ANGIOTENSIN
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Hypertension, nitric oxide, oxidants, and dietary plant polyphenols
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-04-01T18:04:58Z
dc.journal.volume
11
dc.journal.number
8
dc.journal.pagination
837-848
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Galleano, Mónica Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Pechanova, Olga. SLOVAK ACADEMY OF SCIENCES (SAS);
dc.description.fil
Fil: Fraga, César Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.journal.title
Current Pharmaceutical Biotechnology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.2174/138920110793262114
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