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dc.contributor.author
Ferragut, Fátima
dc.contributor.author
Acevedo, Gonzalo Raúl
dc.contributor.author
Gomez, Karina Andrea
dc.date.available
2022-02-08T03:45:42Z
dc.date.issued
2021-06
dc.identifier.citation
Ferragut, Fátima; Acevedo, Gonzalo Raúl; Gomez, Karina Andrea; T Cell Specificity: A Great Challenge in Chagas Disease; Frontiers Media; Frontiers in Immunology; 12; 674078; 6-2021; 1-15
dc.identifier.uri
http://hdl.handle.net/11336/151534
dc.description.abstract
The CD4+ and CD8+ T cell immune response against T. cruzi, the parasite causing Chagas disease, are relevant for both parasite control and disease pathogenesis. Several studies have been focused on their phenotype and functionally, but only a few have drilled down to identify the parasite proteins that are processed and presented to these cells, especially to CD4+ T lymphocytes. Although approximately 10,000 proteins are encoded per haploid T. cruzi genome, fewer than 200 T cell epitopes from 49 T. cruzi proteins have been identified so far. In this context, a detailed knowledge of the specific targets of T cell memory response emerges as a prime tool for the conceptualization and development of prophylactic or therapeutic vaccines, an approach with great potential to prevent and treat this chronic disease. Here, we review the available information about this topic in a comprehensive manner and discuss the future challenges in the field.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CHAGAS DISEASE
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HUMAN MODEL
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MOUSE MODEL
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T CELL SPECIFICITY
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TRYPANOSOMA CRUZI
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
T Cell Specificity: A Great Challenge in Chagas Disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-12-13T18:50:36Z
dc.identifier.eissn
1664-3224
dc.journal.volume
12
dc.journal.number
674078
dc.journal.pagination
1-15
dc.journal.pais
Suiza
dc.description.fil
Fil: Ferragut, Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Acevedo, Gonzalo Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Gomez, Karina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.journal.title
Frontiers in Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fimmu.2021.674078
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