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dc.contributor.author
Cardoso, Estela M.del Lujan
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dc.contributor.author
Contreras, Liliana
dc.contributor.author
Tumilasci, Elida G.
dc.contributor.author
Elbert, Alicia
dc.contributor.author
Aguirre, Elvira C.
dc.contributor.author
Aquilano, Daniel R.
dc.contributor.author
Arregger, Alejandro Luis
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dc.date.available
2017-04-11T15:42:35Z
dc.date.issued
2011-07
dc.identifier.citation
Cardoso, Estela M.del Lujan; Contreras, Liliana; Tumilasci, Elida G.; Elbert, Alicia; Aguirre, Elvira C.; et al.; Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease; Oxford University Press; Nephrology Dialysis Transplantation; 26; 2; 7-2011; 667-683
dc.identifier.issn
0931-0509
dc.identifier.uri
http://hdl.handle.net/11336/15131
dc.description.abstract
BACKGROUND: Hypogonadism is frequent in patients with end-stage renal disease (ESRD). Salivary testosterone (Sal-T) is a non-invasive tool to screen androgen deficiency in adult male with normal renal function. However, available data on its utility in ESRD are not conclusive. OBJECTIVES: The objectives of the study were: (i) to compare free testosterone fractions in saliva (SAL-T) and serum (Free-T); (ii) to establish the correlation of Sal-T with circulating total (TT) and bioavailable testosterone (Bio-T); (iii) to detect androgen deficiency through SalT; (iv) to determine the correlation of Sal-T with clinical parameters. METHODS: The study included: 60 adult ESRD men on haemodialysis (20–60 years old) with decreased libido referred from two dialysis centres; 112 eugonadic and 40 hypogonadic adult men with normal renal function as controls. Simultaneous morning saliva and serum samples were obtained for testosterone measurements by liquid RIA (SAL-T; TT). Free-T and Bio-T were calculated by the Vermeulen equation. RESULTS: Sal-T (0.338 ± 0.177 nM) and Free-T (0.338 ± 0.165 nM) did not differ (P > 0.900) in ESRD as well as in control (0.337 ± 0.182 and 0.337 ± 0.172 nM, respectively; P > 0.900). Sal-T levels correlated positively (P < 0.0001) with Free-T (r = 0.95), TT (r = 0.80) and Bio-T (r = 0.76) in ESRD. Sal-T negatively correlated with age and years on dialytic therapy. Sal-T showed 100% sensitivity and specificity to differentiate patients with androgen deficiency (22%) from those with normal androgen levels (78%). Hypogonadism was hypergonadotrophic in 69% cases and hypogonadotrophic in 31%. CONCLUSIONS: These data demonstrate the value of morning Sal-T testing as a non-invasive approach to screen androgen status in ESRD patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
End Stage Renal Disease
dc.subject
Male Androgen Deficiency
dc.subject
Haemodialysis
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Salivary Testosterone
dc.subject
Serum Testosterone
dc.subject.classification
Endocrinología y Metabolismo
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Salivary testosterone for the diagnosis of androgen deficiency in end-stage renal disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-04-07T15:16:52Z
dc.journal.volume
26
dc.journal.number
2
dc.journal.pagination
667-683
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Oxford
dc.description.fil
Fil: Cardoso, Estela M.del Lujan. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
dc.description.fil
Fil: Contreras, Liliana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Tumilasci, Elida G.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Elbert, Alicia. Centro de Estudios Renales e Hipertención Arterial; Argentina
dc.description.fil
Fil: Aguirre, Elvira C.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Aquilano, Daniel R.. Instituto de Análisis Bioquímicos de Endodrinología; Argentina
dc.description.fil
Fil: Arregger, Alejandro Luis. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.journal.title
Nephrology Dialysis Transplantation
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/ndt/gfq439
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfq439
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