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dc.contributor.author
Grand, Maxime  
dc.contributor.author
Blancato, Victor Sebastian  
dc.contributor.author
Espariz, Martin  
dc.contributor.author
Deutscher, Josef  
dc.contributor.author
Pikis, Andreas  
dc.contributor.author
Hartke, Axel  
dc.contributor.author
Magni, Christian  
dc.contributor.author
Sauvageot, Nicolas  
dc.date.available
2022-02-03T18:50:43Z  
dc.date.issued
2019-11  
dc.identifier.citation
Grand, Maxime; Blancato, Victor Sebastian; Espariz, Martin; Deutscher, Josef; Pikis, Andreas; et al.; Enterococcus faecalis MalR acts as a repressor of the maltose operons and additionally mediates their catabolite repression via direct interaction with seryl-phosphorylated-HPr; Wiley Blackwell Publishing, Inc; Molecular Microbiology; 113; 2; 11-2019; 464-477  
dc.identifier.issn
0950-382X  
dc.identifier.uri
http://hdl.handle.net/11336/151307  
dc.description.abstract
Enterococci are gram-positive pathogens and lead to cause hospital-acquired infections worldwide. Central carbon metabolism was shown as highly induced in Enterococcus faecalis during infection context. Metabolism of α-polysaccharides was previously described as an important factor for host colonisation and biofilm formation. A better characterisation of the adaptation of this bacterium to carbohydrate availabilities may lead to a better understanding of the link between carbohydrate metabolism and the infection process of E. faecalis. Here we show that MalR, a LacI/GalR transcriptional regulator, is the main factor in the regulation of the two divergent operons involved in maltose metabolism in this bacterium. The malR gene is transcribed from the malP promoter, but also from an internal promoter inside the gene located upstream of malR. In the absence of maltose, MalR acts as a repressor and in the presence of glucose, it exerts efficient CcpA-independent carbon catabolite repression. The central PTS protein P-Ser-HPr interacts directly with MalR and enhances its DNA binding capacity, which allows E. faecalis to adapt its metabolism to environmental conditions.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley Blackwell Publishing, Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
METABOLISM  
dc.subject
MALTOSE  
dc.subject
ENTEROCOCCUS  
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REGULATION  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Enterococcus faecalis MalR acts as a repressor of the maltose operons and additionally mediates their catabolite repression via direct interaction with seryl-phosphorylated-HPr  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-11-25T17:57:09Z  
dc.journal.volume
113  
dc.journal.number
2  
dc.journal.pagination
464-477  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Grand, Maxime. Universite de Caen Basse Normandie; Francia  
dc.description.fil
Fil: Blancato, Victor Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina  
dc.description.fil
Fil: Espariz, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina  
dc.description.fil
Fil: Deutscher, Josef. Université Paris-Saclay; Francia. Universite de Paris; Francia  
dc.description.fil
Fil: Pikis, Andreas. Center For Drug Evaluation And Research; Estados Unidos  
dc.description.fil
Fil: Hartke, Axel. Universite de Caen Basse Normandie; Francia  
dc.description.fil
Fil: Magni, Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina  
dc.description.fil
Fil: Sauvageot, Nicolas. Universite de Caen Basse Normandie; Francia  
dc.journal.title
Molecular Microbiology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/mmi.14431  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/mmi.14431