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dc.contributor.author
Machado, Ivana Noelia
dc.contributor.author
Gonzalez, Patricia Verónica
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Schiöth, Helgi Birgir
dc.contributor.author
Lasaga, Mercedes Isabel
dc.contributor.author
Scimonelli, Teresa Nieves
dc.date.available
2017-04-10T21:09:09Z
dc.date.issued
2010-11
dc.identifier.citation
Machado, Ivana Noelia; Gonzalez, Patricia Verónica; Schiöth, Helgi Birgir; Lasaga, Mercedes Isabel; Scimonelli, Teresa Nieves; α-Melanocyte-stimulating hormone (α-MSH) reverses impairment of memory reconsolidation induced by interleukin-1 beta (IL-1 beta) hippocampal infusions; Elsevier Inc; Peptides; 31; 11; 11-2010; 2141-2144
dc.identifier.issn
0196-9781
dc.identifier.uri
http://hdl.handle.net/11336/15117
dc.description.abstract
Interleukin-1 beta (IL-1β) significantly influences cognitive processes. Treatments which raise the level of IL-1β in the brain impair memory consolidation in contextual fear conditioning. However, the effect of IL-1β on memory reconsolidation has not yet been established. The melanocortin α-melanocyte-stimulating hormone (α-MSH) exerts potent anti-inflammatory actions by antagonizing the effect of proinflammatory cytokines. Five subtypes of melanocortin receptors (MC1R–MC5R) have been identified, of which MC3R and MC4R are predominant in the central nervous system. The present experiments show that the injection of IL-1β (5 ng/0.25 μl) in dorsal hippocampus up to 30 min after re-exposition to the context decreases freezing during the contextual fear test. Impairment of memory reconsolidation was reversed by treatment with α-MSH (0.05 μg/0.25 μl). Administration of the MC4 receptor antagonist HS014 (0.5 μg/0.25 μl) blocked the effect of α-MSH. These results suggest that IL-1β may influence memory reconsolidation and that activation of central MC4R could lead to improve cognitive performance.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Memory Reconsolidation
dc.subject
Il-1 Β
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Α-Msh
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Hippocampus
dc.subject.classification
Otras Ciencias Médicas
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Otras Ciencias Médicas
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
α-Melanocyte-stimulating hormone (α-MSH) reverses impairment of memory reconsolidation induced by interleukin-1 beta (IL-1 beta) hippocampal infusions
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-04-07T14:27:37Z
dc.journal.volume
31
dc.journal.number
11
dc.journal.pagination
2141-2144
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Machado, Ivana Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Farmacología Experimental de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
dc.description.fil
Fil: Gonzalez, Patricia Verónica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Farmacología Experimental de Córdoba; Argentina
dc.description.fil
Fil: Schiöth, Helgi Birgir. Uppsala University; Suecia
dc.description.fil
Fil: Lasaga, Mercedes Isabel. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biología Celular e Histología. Centro de Investigación en Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Scimonelli, Teresa Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Farmacología Experimental de Córdoba; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Farmacologia; Argentina
dc.journal.title
Peptides
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S019697811000330X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.peptides.2010.07.018


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