Artículo
Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models
Giolito, María Virginia; Camacho, Cristián Matías
; Martinez Amezaga, Maitena
; Traficante, Carla Inés
; Giordano, Rocío Anabel; Cornier, Patricia Griselda
; Mata, Ernesto Gabino
; Delpiccolo, Carina Maria Lujan
; Boggian, Dora Bernarda; del Giúdice, Antonela
; Mainetti, Leandro Ernesto
; Scharovsky, Olga Graciela
; Rozados, Viviana Rosa
; Rico, María José
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Fecha de publicación:
03/2020
Editorial:
Future Medicine
Revista:
Future Science OA
ISSN:
2056-5623
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Aim: According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action.
Materials & methods: We describe in vitro studies evaluating the effect of 35 novel chemical compounds on two triple negative murine mammary adenocarcinoma tumors.
Results & conclusion: Three compounds were selected because of their high antitumor activity and their low toxicity to normal cells. Their effect on tumor cells apoptosis, clonogenicity and migratory capacity, were determined. We found that the selected compounds showed inhibition of viability and clonogenic capacity, and promotion of apoptosis. They also decreased the migratory capacity of tumor cells. The results obtained suggest the likelihood of their future use as antitumor and/or antimetastatic agents. Lay abstract In spite of the important progress achieved in cancer therapeutics, the percentage of people dying because of cancer is still high. Hence, we need to develop new, effective and nontoxic anticancer agents. We synthetized novel compounds and tested their antitumor effect and toxicity, in order to choose those that are effective and do not affect normal cells and therefore, are suitable for human cancer therapies. We selected three out of 35 compounds that show high antitumor action and low toxicity. Also, we studied the mechanisms by which that effect was achieved. Our next goal is to develop experiments with animals in order to have preclinical data that, hopefully, will lead to the clinical use of one or more of the selected compounds.
Lay abstract: In spite of the important progress achieved in cancer therapeutics, the percentage of people dying because of cancer is still high. Hence, we need to develop new, effective and nontoxic anticancer agents. We synthetized novel compounds and tested their antitumor effect and toxicity, in order to choose those that are effective and do not affect normal cells and therefore, are suitable for human cancer therapies. We selected three out of 35 compounds that show high antitumor action and low toxicity. Also, we studied the mechanisms by which that effect was achieved. Our next goal is to develop experiments with animals in order to have preclinical data that, hopefully, will lead to the clinical use of one or more of the selected compounds.
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Identificadores
Colecciones
Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO
Articulos de INST.DE QUIMICA ROSARIO
Citación
Giolito, María Virginia; Camacho, Cristián Matías; Martinez Amezaga, Maitena; Traficante, Carla Inés; Giordano, Rocío Anabel; et al.; Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models; Future Medicine; Future Science OA; 6; 3; 3-2020; 1-11
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