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dc.contributor.author
Camal Ruggieri, Iván Nadir
dc.contributor.author
Cícero, Andrés Mauricio
dc.contributor.author
Issa, Joao Paulo Mardegan
dc.contributor.author
Feldman, Sara
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dc.date.available
2022-02-01T14:29:19Z
dc.date.issued
2021-05
dc.identifier.citation
Camal Ruggieri, Iván Nadir; Cícero, Andrés Mauricio; Issa, Joao Paulo Mardegan; Feldman, Sara; Bone fracture healing: perspectives according to molecular basis; Springer Tokyo; Journal of Bone and Mineral Metabolism; 39; 3; 5-2021; 311-331
dc.identifier.issn
0914-8779
dc.identifier.uri
http://hdl.handle.net/11336/151063
dc.description.abstract
Fractures have a great impact on health all around the world and with fracture healing optimization; this problem could be resolved partially. To make a practical contribution to this issue, the knowledge of bone tissue, cellularity, and metabolism is essential, especially cytoskeletal architecture and its transformations according to external pressures. Special physical and chemical characteristics of the extracellular matrix (ECM) allow the transmission of mechanical stimuli from outside the cell to the plasmatic membrane. The osteocyte cytoskeleton is conformed by a complex network of actin and microtubules combined with crosslinker proteins like vinculin and fimbrin, connecting and transmitting outside stimuli through EMC to cytoplasm. Herein, critical signaling pathways like Cx43-depending ones, MAPK/ERK, Wnt, YAP/TAZ, Rho-ROCK, and others are activated due to mechanical stimuli, resulting in osteocyte cytoskeletal changes and ECM remodeling, altering the tissue and, therefore, the bone. In recent years, the osteocyte has gained more interest and value in relation to bone homeostasis as a great coordinator of other cell populations, thanks to its unique functions. By integrating the latest advances in relation to intracellular signaling pathways, mechanotransmission system of the osteocyte and bone tissue engineering, there are promising experimental strategies, while some are ready for clinical trials. This work aims to show clearly and precisely the integration between cytoskeleton and main molecular pathways in relation to mechanotransmission mechanism in osteocytes, and the use of this theoretical knowledge in therapeutic tools for bone fracture healing.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Tokyo
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BONE FRACTURE HEALING
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MECHANICAL LOADING
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MECHANOSENSING
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MOLECULAR PATHWAY
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OSTEOCYTE
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Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Bone fracture healing: perspectives according to molecular basis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-06T21:01:58Z
dc.identifier.eissn
1435-5604
dc.journal.volume
39
dc.journal.number
3
dc.journal.pagination
311-331
dc.journal.pais
Japón
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dc.journal.ciudad
Tokio
dc.description.fil
Fil: Camal Ruggieri, Iván Nadir. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
dc.description.fil
Fil: Cícero, Andrés Mauricio. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
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Fil: Issa, Joao Paulo Mardegan. Universidade de Sao Paulo; Brasil
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Fil: Feldman, Sara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osteoarticular, Ingeniería Tisular y Terapias Emergentes; Argentina
dc.journal.title
Journal of Bone and Mineral Metabolism
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/10.1007/s00774-020-01168-0
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00774-020-01168-0
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