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dc.contributor.author
Cordoba, Elisa Eugenia
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dc.contributor.author
Lacunza, Ezequiel
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dc.contributor.author
Güerci, Alba Mabel
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dc.date.available
2022-02-01T10:11:49Z
dc.date.issued
2021-12
dc.identifier.citation
Cordoba, Elisa Eugenia; Lacunza, Ezequiel; Güerci, Alba Mabel; Clinical factors affecting the determination of radiotherapy-induced skin toxicity in breast cancer; Korean Society for Radiation Oncology; Radiation Oncology Journal; 39; 4; 12-2021; 315-323
dc.identifier.issn
2234-1900
dc.identifier.uri
http://hdl.handle.net/11336/151037
dc.description.abstract
Purpose:Radiotherapy is essential for the treatment of breast cancer (BC). However, adverse effects may occur in healthy tissue, during treatment and even after several months. Although it is known that this clinical radiosensitivity is multifactorial, the factors involved are unknown yet. In this study, we evaluated the effect of these factors on the development of radiodermatitis in patients undergoing radiotherapy.Materials and MethodsDemographic and lifestyle data collected during face-to-face interviews of 122 BC patients and data from clinical records were investigated. Most patients underwent conventional three-dimensional radiotherapy treatment. A total dose of 50 Gy was administered (2 Gy/day), followed by a boost in a tumor bed with a total dose of 18 Gy (2 Gy/day). Radiotoxicity was evaluated weekly using the Radiation Therapy Oncology Group classification system (range, 0 to 4, according to the severity).ResultsIn the present study, 75.4% of patients presented acute skin toxic effects with different degrees of severity. In 25% of cases, these effects manifested at the end of the fourth week at a cumulative dose of 40 Gy. The association of grade ≥2 acute skin reactions with body mass index (BMI) and breast size and between grade 3?4 and age was positive compared with controls. However, the role of the other factors could not be confirmed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Korean Society for Radiation Oncology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
RADIOTHERAPY
dc.subject
BREAST NEOPLASMS
dc.subject
RADIATION INJURIES
dc.subject
RADIODERMATITIS
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Clinical factors affecting the determination of radiotherapy-induced skin toxicity in breast cancer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-01-25T14:33:03Z
dc.identifier.eissn
2234-3156
dc.journal.volume
39
dc.journal.number
4
dc.journal.pagination
315-323
dc.journal.pais
Corea del Sur
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dc.description.fil
Fil: Cordoba, Elisa Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
dc.description.fil
Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.description.fil
Fil: Güerci, Alba Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina
dc.journal.title
Radiation Oncology Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://e-roj.org/journal/view.php?doi=10.3857/roj.2020.00395
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3857/roj.2020.00395
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