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dc.contributor.author
Prado Fernandes Bernal, Suzan
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Gritti, Micaela Andrea
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Piccin dos Santos,, Viviane
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Ronzella Ottoni, Júlia
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de Oliveira, Valéria Maia
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Peichoto, María Elisa
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Zambrano Passarini, Michel Rodrigo
dc.date.available
2022-01-21T12:28:53Z
dc.date.issued
2021-05
dc.identifier.citation
Prado Fernandes Bernal, Suzan; Gritti, Micaela Andrea; Piccin dos Santos,, Viviane; Ronzella Ottoni, Júlia; de Oliveira, Valéria Maia; et al.; Pharmaceutical biotechnological potential of filamentous fungi isolated from textile industry; Springer; Archives of Microbiology; 203; 7; 5-2021; 3933-3944
dc.identifier.issn
0302-8933
dc.identifier.uri
http://hdl.handle.net/11336/150458
dc.description.abstract
The need for more effective drugs for the treatment of infectious diseases as well as for general applications including wound healing and burn surgery, has guided efforts for the discovery of new compounds of medical interest. Microorganisms found in textile industrial waste have the ability to produce a variety of enzymes and/or secondary metabolites including molecules of pharmaceutical interest. The present work investigated the biotechnological potential of filamentous fungi isolated from textile industry wastewater for the production of collagenase and antimicrobial metabolites. From 28 isolates assayed, Sarocladium sp. ITF33 showed specific collagenolytic activity with values of 7.62 and 9.04 U mg−1 for the intracellular and extracellular fractions, respectively. The isolate Penicillium sp. ITF28 showed the best antimicrobial activity, reaching MIC ranging from 1.0 to 0.0625 mg mL−1 against five pathogenic bacteria. Molecular analyzes suggest that the isolate Sarocladium sp. ITF 33 can be considered a species not yet described. The results of the present work encourage studies of characterization and purification of the enzymes and secondary metabolites produced by the isolates found aiming future applications in the medical and pharmaceutical fields.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
COLLAGENASE
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PHARMACEUTICAL APPLICATION
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PROTEASE
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SECONDARY METABOLITE
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Pharmaceutical biotechnological potential of filamentous fungi isolated from textile industry
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-01-20T13:11:28Z
dc.journal.volume
203
dc.journal.number
7
dc.journal.pagination
3933-3944
dc.journal.pais
Alemania
dc.journal.ciudad
Berlin
dc.description.fil
Fil: Prado Fernandes Bernal, Suzan. Universidade Federal da Integração Latinoamericana; Brasil
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Fil: Gritti, Micaela Andrea. Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Piccin dos Santos,, Viviane. Universidade Estadual de Campinas; Brasil
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Fil: Ronzella Ottoni, Júlia. Universidade Federal da Integração Latinoamericana; Brasil
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Fil: de Oliveira, Valéria Maia. Universidade Estadual de Campinas; Brasil
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Fil: Peichoto, María Elisa. Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Zambrano Passarini, Michel Rodrigo. Universidade Federal da Integração Latinoamericana; Brasil
dc.journal.title
Archives of Microbiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/10.1007/s00203-021-02379-3
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00203-021-02379-3
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