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dc.contributor.author
Cardoso, Estela M.del Lujan
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dc.contributor.author
Arregger, Alejandro Luis
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dc.contributor.author
Monardes, Gloria
dc.contributor.author
Contreras, Liliana Noemi
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dc.date.available
2017-04-07T20:02:21Z
dc.date.issued
2013-05
dc.identifier.citation
Cardoso, Estela M.del Lujan; Arregger, Alejandro Luis; Monardes, Gloria; Contreras, Liliana Noemi; An accurate, non-invasive approach to diagnose Cushing’s syndrome in at-risk populations; Elsevier Inc; Steroids; 78; 5; 5-2013; 476-482
dc.identifier.issn
0039-128X
dc.identifier.uri
http://hdl.handle.net/11336/15015
dc.description.abstract
Background: The prevalence of Cushing’s syndrome (CS) in at-risk populations in developing countries remains uncertain. Evening urinary cortisol (UFC22–23) and salivary cortisol after treatment with 1-mg DST (SAFdex) have seldom been used as diagnostic tools in these populations. Objectives: (1) To establish the prevalence of CS in adults with cortisol-related morbidities using UFC22–23 and SAFdex as markers along with all first-line diagnostic tests recommended for CS; and (2) to assess the performance of each test and define a non-invasive diagnostic approach for CS in at-risk outpatient subjects. Methods: A total of 128 outpatients were evaluated, including type 1 and 2 diabetic patients with poor metabolic control (DM1 and DM2), hypertensive subjects with central obesity (HBP) and premenopausal women with osteoporosis (OS). Controls included 100 healthy volunteers and 23 patients with CS. Total urinary cortisol (UFC), UFC22–23, late-night salivary cortisol (SAF23) and suppression of cortisol levels in saliva (SAFdex) and serum (Fdex) after treatment with 1-mg DST were assessed. Results: CS was diagnosed in one DM2 and one HBP patient; both women exhibited central obesity. Among CS patients, UFC showed more within-person variability than UFC22–23 or SAF23. UFC22–23 and SAF23 were positively and significantly correlated in all groups (r ⩾ 0.70; p ⩽ 0.0001). UFC22–23 > 44.0 ng/mg creatinine or SAF23 > 3.8 nM were 100% sensitive (S) and specific (E) for CS. Furthermore, SAFdex > 2.0 nM or Fdex > 50.0 nM were 100% S and 97.3% E for CS. Conclusion: CS was diagnosed in 1.5% of at-risk patients. The combination of UFC22–23 or SAF23 with SAFdex offers a non-invasive diagnostic tool to assess cortisol nadir and feed-back status in outpatients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Urinary Cortisol
dc.subject
Salivary Cortisol
dc.subject
Dexamethasone Suppression Test
dc.subject
Cushing'S Syndrome
dc.subject.classification
Endocrinología y Metabolismo
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
An accurate, non-invasive approach to diagnose Cushing’s syndrome in at-risk populations
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-04-07T15:16:57Z
dc.journal.volume
78
dc.journal.number
5
dc.journal.pagination
476-482
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Cardoso, Estela M.del Lujan. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
dc.description.fil
Fil: Arregger, Alejandro Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Monardes, Gloria. Universidad de Buenos Aires. Facultad de Odontología; Argentina
dc.description.fil
Fil: Contreras, Liliana Noemi. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
dc.journal.title
Steroids
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0039128X13000391
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.steroids.2013.02.005
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