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dc.contributor.author
Trigila, Anabella Paola  
dc.contributor.author
Pisciottano, Francisco  
dc.contributor.author
Franchini, Lucia Florencia  
dc.date.available
2022-01-14T17:20:21Z  
dc.date.issued
2021-11  
dc.identifier.citation
Trigila, Anabella Paola; Pisciottano, Francisco; Franchini, Lucia Florencia; Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals; BioMed Central; Bmc Biology; 19; 1; 11-2021; 1-24  
dc.identifier.issn
1741-7007  
dc.identifier.uri
http://hdl.handle.net/11336/150123  
dc.description.abstract
Mammals possess unique hearing capacities that differ significantly from those of the rest of the amniotes. In order to gain insights into the evolution of the mammalian inner ear, we aim to identify the set of genetic changes and the evolutionary forces that underlie this process. We hypothesize that genes that impair hearing when mutated in humans or in mice (hearing loss (HL) genes) must play important roles in the development and physiology of the inner ear and may have been targets of selective forces across the evolution of mammals. Additionally, we investigated if these HL genes underwent a human-specific evolutionary process that could underlie the evolution of phenotypic traits that characterize human hearing.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
BioMed Central  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
INNER EAR,  
dc.subject
EVOLUTION  
dc.subject
HEARING LOSS  
dc.subject
MAMMALS  
dc.subject
TSARS  
dc.subject
HARS  
dc.subject.classification
Biología  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Hearing loss genes reveal patterns of adaptive evolution at the coding and non-coding levels in mammals  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-12-13T18:47:34Z  
dc.journal.volume
19  
dc.journal.number
1  
dc.journal.pagination
1-24  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Trigila, Anabella Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina  
dc.description.fil
Fil: Pisciottano, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina  
dc.description.fil
Fil: Franchini, Lucia Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina  
dc.journal.title
Bmc Biology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-01170-6  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/s12915-021-01170-6