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dc.contributor.author
Sookoian, Silvia Cristina
dc.contributor.author
Fernandez Gianotti, Tomas
dc.contributor.author
Burgueño, Adriana Laura
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Pirola, Carlos Jose
dc.date.available
2017-04-07T19:10:18Z
dc.date.issued
2011-12
dc.identifier.citation
Sookoian, Silvia Cristina; Fernandez Gianotti, Tomas; Burgueño, Adriana Laura; Pirola, Carlos Jose; Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research; De Gruyter; Biomolecular Concepts; 2; 6; 12-2011; 445-547
dc.identifier.issn
1868-5021
dc.identifier.uri
http://hdl.handle.net/11336/15006
dc.description.abstract
In this study, we review the current knowledge and recent insights on the role of epigenetic factors in the development of human insulin resistance (IR)- and metabolic syndrome (MS)-related phenotypes, and attempt to lay a framework to consider IR as a potentially reversible incapacity to control metabolic homeostasis that is strongly influenced by the interplay between external and internal cues. We summarize the evidence on how tissue-specific epigenetic markers participate either by activating or repressing the gene expression programs to modulate IR- and MS-associated traits. Some additional data are provided about how the exploration of DNA methylation markers in peripheral blood mononuclear cells potentially offers appealing information about the impact of epigenetics in the pathogenesis of IR. Clues about the relation between IR and impaired intrauterine growth explained by fetal metabolic programming and epigenetic modifications are shown, including novel findings about the impact of histone modifications. For instance, we observed that specific epigenetic factors in genes associated with mitochondrial biogenesis may be associated with birth weight. Furthermore, some prospective ideas about the functional consequences of genetic variation modulated by allele-specific epigenetic markers and its impact on MS susceptibility are also illustrated. Finally, we summarize the current knowledge of epigenetics as the biological rationale for potential therapeutic intervention in IR and MS.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
De Gruyter
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Allele-Specific Epigenetic Marks
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Dna Methylation
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Epigenetic
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Fatty Liver
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Fetal Metabolic Programming
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Histone Deacetylases
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Histone Modifications
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Insulin Resistance
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Intrauterine Growth
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Large for Gestational Age
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Metabolic Syndrome
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Mtdna Copy Number
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Pgc1a
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Ppargc1a
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Small for Gestational Age
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Genética Humana
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-04-07T15:16:36Z
dc.identifier.eissn
1868-503X
dc.journal.volume
2
dc.journal.number
6
dc.journal.pagination
445-547
dc.journal.pais
Alemania
dc.journal.ciudad
Berlín
dc.description.fil
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Fernandez Gianotti, Tomas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
dc.description.fil
Fil: Burgueño, Adriana Laura. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Pirola, Carlos Jose. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
dc.journal.title
Biomolecular Concepts
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/bmc.2011.2.issue-6/bmc.2011.043/bmc.2011.043.xml
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1515/BMC.2011.043


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