Artículo
Amidinoquinoxaline-Based Nitrones as Lipophilic Antioxidants
Gruber, Nadia
; Orelli, Liliana Raquel
; Minnelli, Cristina; Mangano, Luca; Laudadio, Emiliano; Mobbili, Giovanna; Stipa, Pierluigi
Fecha de publicación:
08/2021
Editorial:
MDPI
Revista:
Antioxidants
ISSN:
2076-3921
e-ISSN:
2076-3921
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The potential of nitrones (N-oxides) as therapeutic antioxidants is due to their ability to counteract oxidative stress, mainly attributed to their action as radical scavengers toward C- and O-centered radicals. Among them, nitrones from the amidinoquinoxaline series resulted in interesting derivatives, due to the ease with which it is possible to introduce proper substituents within their structure in order to modulate their lipophilicity. The goal is to obtain lipophilic antioxidants that are able to interact with cell membranes and, at the same time, enough hydrophilic to neutralize those radicals present in a water compartment. In this work, the antioxidant efficacy of a series of amidinoquinoxaline nitrones has been evaluated regarding the oxidation of 2-deoxyribose and lipid peroxidation. The results have been rationalized on the basis of the different possible mechanisms involved, depending on some of their properties, such as lipophilicity, the ability to scavenge free radicals, and to undergo single electron transfer (SET) reactions.
Palabras clave:
ANTIOXIDANTS
,
NITRONES
,
SPIN TRAPPING
,
ROS
,
DFT
,
FREE RADICALS
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Gruber, Nadia; Orelli, Liliana Raquel; Minnelli, Cristina; Mangano, Luca; Laudadio, Emiliano; et al.; Amidinoquinoxaline-Based Nitrones as Lipophilic Antioxidants; MDPI; Antioxidants; 10; 8; 8-2021; 1185-1195
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