Artículo

A standard numbering scheme for class C β-lactamases

Mack, Andrew R.; Barnes, Melissa D.; Taracila, Magdalena A.; Hujer, Andrea M.; Hujer, Kristine M.; Cabot, Gabriel; Feldgarden, Michael; Haft, Daniel H.; Klimke, William; Van Den Akker, Focco; Vila, Alejandro JoseIcon ; Smania, AndreaIcon ; Haider, Shozeb; Papp Wallace, Krisztina M.; Bradford, Patricia A.; Rossolini, Gian Maria; Docquier, Jean Denis; Frère, Jean Marie; Galleni, Moreno; Hanson, Nancy D.; Oliver, Antonio; Plésiat, Patrick; Poirel, Laurent; Nordmann, Patrice; Palzkill, Timothy G.; Jacoby, George A.; Bush, Karen; Bonomo, Robert A.
Fecha de publicación: 11/2019
Editorial: American Society for Microbiology
Revista: Antimicrobial Agents and Chemotherapy
ISSN: 0066-4804
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications.
Palabras clave: AMINO ACID NUMBERING , AMPC , BETA-LACTAMASES , CLASS C BETA-LACTAMASE , CONSERVED RESIDUE , NOMENCLATURE , STRUCTURE-ACTIVITY RELATIONSHIPS
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/149998
URL: https://journals.asm.org/doi/10.1128/AAC.01841-19
DOI: http://dx.doi.org/10.1128/AAC.01841-19
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Articulos(IBR)
Articulos de INST.DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Citación
Mack, Andrew R.; Barnes, Melissa D.; Taracila, Magdalena A.; Hujer, Andrea M.; Hujer, Kristine M.; et al.; A standard numbering scheme for class C β-lactamases; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 64; 3; 11-2019; 1-16
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