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dc.contributor.author
Jacobsen, Dario Gustavo
dc.contributor.author
Gonzalez, D.
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Jamardo, J.
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Ibar, C.
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Pugliese, L.
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Fortuna, F.
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Carrizo, E.
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Caro, E. M.
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Perazzi, Beatriz Elizabeth
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Repetto, Esteban Martín
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Reboredo, G.
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Fabre, B.
dc.date.available
2022-01-07T22:35:43Z
dc.date.issued
2021-05
dc.identifier.citation
Jacobsen, Dario Gustavo; Gonzalez, D.; Jamardo, J.; Ibar, C.; Pugliese, L.; et al.; Clinical Performance of Two Methods for Detecting Anti SARS-CoV-2 Antibodies; Austin Publishing Group; Journal of Immune Research; 7; 2; 5-2021; 1-3
dc.identifier.uri
http://hdl.handle.net/11336/149842
dc.description.abstract
Evaluating the clinical performance of available methods to detect antibodies against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has become a primordial issue in clinical laboratories. The aim of this study was to evaluate the clinical performance of two methods for SARS-CoV-2 antibodies detection, an automated Chemiluminescent Immunoassay (CLIA) and an immunochromatographic Lateral-Flow Assay (LFA) in patients with positive reverse transcription polymerase chain reaction (RT-PCR). Performance for CLIA method was Positive Agreement (PA) 56.6% and Negative Agreement (NA) 96,6% for IgM and PA 85.8%/NA 90,2% for IgG. Performance for LFA method was PA 56.2% and NA 100% for IgM and PA 95.5% and NA 100 % for IgG. LFA general agreement IgG was better than CLIA. In both methods, significant differences in Kappa index are observed when IgG and IgM are compared. When evaluating the data from a clinical perspective, we found that both method performance for IgM detection may not meet the expected requirements for their clinical utility and could lead to an inappropriate medical decision. The findings of this study show that both immunoassay methods might be reliable for assessing immunological response in COVID-19 patients. Our results also confirm that IgG measurement could be helpful, especially for epidemiological studies in our population. These results provide evidence to justify epidemiological studies in our population.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Austin Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Clinical Performance
dc.subject
SARS-CoV-2
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COVID-19
dc.subject.classification
Enfermedades Infecciosas
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Clinical Performance of Two Methods for Detecting Anti SARS-CoV-2 Antibodies
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-01-06T13:45:20Z
dc.identifier.eissn
2471-0261
dc.journal.volume
7
dc.journal.number
2
dc.journal.pagination
1-3
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Jacobsen, Dario Gustavo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
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Fil: Gonzalez, D.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
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Fil: Jamardo, J.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
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Fil: Ibar, C.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
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Fil: Pugliese, L.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
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Fil: Fortuna, F.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
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Fil: Carrizo, E.. Coordinadora de Salud Misionar; Argentina
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Fil: Caro, E. M.. Laboratorio Biogenar; Argentina
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Fil: Perazzi, Beatriz Elizabeth. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
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Fil: Repetto, Esteban Martín. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Reboredo, G.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
dc.description.fil
Fil: Fabre, B.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Fisiopatología y Bioquímica Clínica; Argentina
dc.journal.title
Journal of Immune Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://austinpublishinggroup.com/immune-research/fulltext/immunes-v7-id1040.php
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.26420/jimmunres.2021.1040
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