Artículo
Co-Occurrence of NDM-5 and RmtB in a Clinical Isolate of Escherichia coli Belonging to CC354 in Latin America
Costa, Agustina
; Figueroa Espinosa, Roque Arnulfo
; Gaudenzi, Florencia; Lincopan, Nilton; Fuga, Bruna; Ghiglione, Barbara
; Gutkind, Gabriel Osvaldo
; Di Conza, José Alejandro
Fecha de publicación:
04/2021
Editorial:
Frontiers Media
Revista:
Frontiers in Cellular and Infection Microbiology
ISSN:
2235-2988
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
New Delhi metallo-β-lactamase (NDM)-producing isolates are usually resistant to most β-lactams and other antibiotics as a result of the coexistence of several resistance markers, and they cause a variety of infections associated to high mortality rates. Although NDM-1 is the most prevalent one, other variants are increasing their frequency worldwide. In this study we describe the first clinical isolate of NDM-5- and RmtB-producing Escherichia coli in Latin America. E. coli (Ec265) was recovered from a urine sample of a female outpatient. Phenotypical and genotypical characterization of resistance markers and conjugation assays were performed. Genetic analysis of Ec265 was achieved by whole genome sequencing. Ec265 belonging to ST9693 (CC354), displayed resistance to most β-lactams (including carbapenems), aminoglycosides (gentamicin and amikacin), and quinolones. Several resistance genes were found, including blaNDM-5 and rmtB, located on a conjugative plasmid. blaNDM-5 genetic context is similar to others found around the world. Co-transfer of multiple antimicrobial resistance genes represents a particular challenge for treatment in clinical settings, whereas the spread of pathogens resistant to last resort antibiotics should raise an alarm in the healthcare system worldwide.
Palabras clave:
ANTIBIOTIC MULTI-RESISTANCE
,
ESCHERICHIA COLI
,
METALLO-Β-LACTAMASE
,
NDM-5
,
RMTB
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Costa, Agustina; Figueroa Espinosa, Roque Arnulfo; Gaudenzi, Florencia; Lincopan, Nilton; Fuga, Bruna; et al.; Co-Occurrence of NDM-5 and RmtB in a Clinical Isolate of Escherichia coli Belonging to CC354 in Latin America; Frontiers Media; Frontiers in Cellular and Infection Microbiology; 11; 4-2021; 1-6
Compartir
Altmétricas