Artículo
Immunoglobulin G Immune Complexes May Contribute to Neutrophil Activation in the Course of Severe Coronavirus Disease 2019
Mazzitelli, Ignacio Gabriel
; Bleichmar, Lucia; Ludueña, María Guillermina; Pisarevsky, Andrea; Labato, Mariana; Chiaradia, Verónica; Finocchieto, Paola; Paulin, Francisco; Hormanstorfer, Macarena; Baretto, María Constanza; Adanza, Santiago Piombi; Parodi, María Noel; Ragusa, Martín; Melucci Ganzarain, Claudia del Carmen
; Erra Diaz, Fernando Alberto
; Paletta, Ana Luz
; Di Diego García, Facundo
; Ceballos, Ana
; Geffner, Jorge Raúl
Fecha de publicación:
04/2021
Editorial:
University of Chicago Press
Revista:
Journal Of Infectious Diseases
ISSN:
0022-1899
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Severe coronavirus disease 2019 (COVID-19) is associated with an overactive inflammatory response mediated by macrophages. Here, we analyzed the phenotype and function of neutrophils in patients with COVID-19. We found that neutrophils from patients with severe COVID-19 express high levels of CD11b and CD66b, spontaneously produce CXCL8 and CCL2, and show a strong association with platelets. Production of CXCL8 correlated with plasma concentrations of lactate dehydrogenase and D-dimer. Whole blood assays revealed that neutrophils from patients with severe COVID-19 show a clear association with immunoglobulin G (IgG) immune complexes. Moreover, we found that sera from patients with severe disease contain high levels of immune complexes and activate neutrophils through a mechanism partially dependent on FcγRII (CD32). Interestingly, when integrated in immune complexes, anti-severe acute respiratory syndrome coronavirus 2 IgG antibodies from patients with severe COVID-19 displayed a higher proinflammatory profile compared with antibodies from patients with mild disease. Our study suggests that IgG immune complexes might promote the acquisition of an inflammatory signature by neutrophils, worsening the course of COVID-19.
Palabras clave:
CD32
,
COVID-19
,
CXCL8
,
IMMUNE COMPLEXES
,
INFLAMMATION
,
NEUTROPHILS
,
SARS-COV-2
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INBIRS)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Citación
Mazzitelli, Ignacio Gabriel; Bleichmar, Lucia; Ludueña, María Guillermina; Pisarevsky, Andrea; Labato, Mariana; et al.; Immunoglobulin G Immune Complexes May Contribute to Neutrophil Activation in the Course of Severe Coronavirus Disease 2019; University of Chicago Press; Journal Of Infectious Diseases; 224; 4; 4-2021; 575-585
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