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dc.contributor.author
Ghanbari, Kazhal
dc.contributor.author
Roshani, Mahmoud
dc.contributor.author
Goicoechea, Hector Casimiro
dc.contributor.author
Jalalvand, Ali R.
dc.date.available
2022-01-05T02:59:30Z
dc.date.issued
2019-10
dc.identifier.citation
Ghanbari, Kazhal; Roshani, Mahmoud; Goicoechea, Hector Casimiro; Jalalvand, Ali R.; Developing an elegant and integrated electrochemical-theoretical approach for detection of DNA damage induced by 4-nonylphenol; Elsevier; Heliyon; 5; 10; 10-2019; 1-9
dc.identifier.issn
2405-8440
dc.identifier.uri
http://hdl.handle.net/11336/149606
dc.description.abstract
In this work, a novel biosensor was fabricated for detection of DNA damage induced by 4-nonylphenol (NP) and also determination of NP. To achieve this goal, a glassy carbon electrode (GCE) was modified with chitosan (Chit), gold nanoparticles (Au NPs) and DNA-multiwalled carbon nanotubes (DNA-MWCNTs). Then, the DNA-MWCNTs/Au NPs/Chit/GCE was incubated with methylene blue (MB) to obtain MB-DNA-MWCNTs/Au NPs/Chit/GCE in which MB was used as the redox indicator. The modifications applied to the GCE were characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopic (EDS) and theoretical evidence. MB is a derivative of anthraquinone which can intercalate into double helix structure of DNA. By treating MB-DNA-MWCNTs/Au NPs/Chit/GCE with NP, a higher Rct was observed because the insertion of the NP may result in a more negative charge environment on the DNA surface which hinders accessibility of [Fe(CN)6]3-/4- anion to the electrode surface. Change in the EIS response of the biosensor in the presence of NP was used to develop a novel system for monitoring the DNA damage induced by NP. The EIS technique was also used to develop a sensitive electroanalytical method for determination of NP.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
4-NONYLPHENOL
dc.subject
ANALYTICAL CHEMISTRY
dc.subject
DNA DAMAGE
dc.subject
ELECTROCHEMICAL BIOSENSOR
dc.subject
ELECTROCHEMISTRY
dc.subject.classification
Química Analítica
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Developing an elegant and integrated electrochemical-theoretical approach for detection of DNA damage induced by 4-nonylphenol
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-27T18:47:20Z
dc.journal.volume
5
dc.journal.number
10
dc.journal.pagination
1-9
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Ghanbari, Kazhal. Ilam University; Irán
dc.description.fil
Fil: Roshani, Mahmoud. Ilam University; Irán
dc.description.fil
Fil: Goicoechea, Hector Casimiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Desarrollo Analítico y Quimiometría; Argentina
dc.description.fil
Fil: Jalalvand, Ali R.. Kermanshah University of Medical Sciences; Irán
dc.journal.title
Heliyon
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.heliyon.2019.e02755
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/heliyon/fulltext/S2405-8440(19)36415-1
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