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dc.contributor.author
Prado Acosta, Mariano
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dc.contributor.author
Lepenies, Bernd
dc.date.available
2022-01-04T18:44:33Z
dc.date.issued
2019-11
dc.identifier.citation
Prado Acosta, Mariano; Lepenies, Bernd; Bacterial glycans and their interactions with lectins in the innate immune system; Journal of the Serbian Chemical Society; Biochemical Society Transactions; 47; 6; 11-2019; 1569-1579
dc.identifier.uri
http://hdl.handle.net/11336/149591
dc.description.abstract
Bacterial surfaces are rich in glycoconjugates that are mainly present in their outer layers and are of great importance for their interaction with the host innate immune system. The innate immune system is the first barrier against infection and recognizes pathogens via conserved pattern recognition receptors (PRRs). Lectins expressed by innate immune cells represent an important class of PRRs characterized by their ability to recognize carbohydrates. Among lectins in innate immunity, there are three major classes including the galectins, siglecs, and C-type lectin receptors. These lectins may contribute to initial recognition of bacterial glycans, thus providing an early defence mechanism against bacterial infections, but they may also be exploited by bacteria to escape immune responses. In this review, we will first exemplify bacterial glycosylation systems; we will then describe modes of recognition of bacterial glycans by lectins in innate immunity and, finally, we will briefly highlight how bacteria have found ways to exploit these interactions to evade immune recognition.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Journal of the Serbian Chemical Society
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BACTERIA
dc.subject
GLYCOSYLATION
dc.subject
IMMUNOMODULATION
dc.subject
INNATE IMMUNITY
dc.subject
LECTINS
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Bacterial glycans and their interactions with lectins in the innate immune system
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-12-01T16:25:45Z
dc.identifier.eissn
1470-8752
dc.journal.volume
47
dc.journal.number
6
dc.journal.pagination
1569-1579
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Prado Acosta, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Leibniz Universitat Hannover; Alemania
dc.description.fil
Fil: Lepenies, Bernd. Leibniz Universitat Hannover; Alemania
dc.journal.title
Biochemical Society Transactions
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1042/BST20170410
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://portlandpress.com/biochemsoctrans/article-abstract/47/6/1569/221126
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