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dc.contributor.author
Peleg Raibstein, Daría
dc.contributor.author
Hauser, Jonas
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Llano Lopez, Luis H.
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Feldon, Joram
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Gargiulo, Pascual Angel
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Yee, Benjamín K.
dc.date.available
2017-04-07T14:59:30Z
dc.date.issued
2013-02
dc.identifier.citation
Peleg Raibstein, Daría; Hauser, Jonas; Llano Lopez, Luis H.; Feldon, Joram; Gargiulo, Pascual Angel; et al.; Baseline prepulse inhibition expression predicts the propensity of developing sensitization to the motor stimulant effects of amphetamine in C57BL/6 mice; Springer; Psychopharmacology; 225; 2; 2-2013; 341-352
dc.identifier.issn
0033-3158
dc.identifier.uri
http://hdl.handle.net/11336/14952
dc.description.abstract
Rationale The startle reflex to a sudden intense acoustic pulse stimulus is attenuated if the pulse is shortly preceded by a weak prepulse stimulus. This represents a form of sensory gating, known as prepulse inhibition (PPI), observable across species. PPI is modulated by dopamine and readily disrupted by acute amphetamine. Prior repeated exposures to amphetamine also disrupt PPI even when the drug is not present during test, suggesting that a sensitized mesolimbic dopamine system—inducible even by a single exposure to amphetamine—might be responsible. However, this causative link has been challenged by inconsistent efficacy between different amphetamine pre-treatment regimes, which all robustly sensitize the behavioral response to amphetamine.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Pre-Pulse
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Inhibition
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Dopamine
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Amphetamine
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Ppi
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Psychostimulant Drugs
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Schizophrenia
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Sensitization
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Sensorimotor Gating
dc.subject.classification
Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Baseline prepulse inhibition expression predicts the propensity of developing sensitization to the motor stimulant effects of amphetamine in C57BL/6 mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-09-19T18:46:19Z
dc.journal.volume
225
dc.journal.number
2
dc.journal.pagination
341-352
dc.journal.pais
Alemania
dc.journal.ciudad
Berlin
dc.description.fil
Fil: Peleg Raibstein, Daría. Swiss Federal Institute of Technology Zurich. Laboratory of Behavioural Neurobiology; Alemania
dc.description.fil
Fil: Hauser, Jonas. Swiss Federal Institute of Technology Zurich. Laboratory of Behavioural Neurobiology; Alemania
dc.description.fil
Fil: Llano Lopez, Luis H.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Feldon, Joram. Swiss Federal Institute of Technology Zurich. Laboratory of Behavioural Neurobiology; Alemania
dc.description.fil
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Yee, Benjamín K.. Swiss Federal Institute of Technology Zurich. Laboratory of Behavioural Neurobiology; Alemania
dc.journal.title
Psychopharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00213-012-2819-5
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00213-012-2819-5
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