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dc.contributor.author
Han, Yong Ki  
dc.contributor.author
Simionato, Laura Daniela  
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Calvo, Romina Giselle  
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Mattei, M. Belén  
dc.contributor.author
Segall, Adriana Ines  
dc.contributor.other
Haddad Kury, Charbell Miguel  
dc.date.available
2021-12-29T16:09:25Z  
dc.date.issued
2021  
dc.identifier.citation
Han, Yong Ki; Simionato, Laura Daniela; Calvo, Romina Giselle; Mattei, M. Belén; Segall, Adriana Ines; A Comparative Analysis of Dissolution Profiles of Furosemide Tablets Available in the Argentinean Market (Part 2); BP International; 9; 2021; 81-92  
dc.identifier.isbn
978-93-91312-23-7  
dc.identifier.uri
http://hdl.handle.net/11336/149390  
dc.description.abstract
The rate and the extent of drug dissolution and its absorption depend on the characteristics of the active pharmaceutical ingredient (API) as well as the dosage form properties. In this work dissolution profiles of furosemide tablets of nine commercial products marketed in Argentine were evaluated. All Brands fulfill the specifications of dissolution test of USP. Comparison of dissolution profiles were carried out by model-dependent and model independent approaches. The Weibull model provided the best kinetic curve adjustment. Brands IV, VI and IX had the best fitting, with the maximum determination coefficient and the smallest AIC values. Results obtained via model-independent approach show that there was not significative difference in Dissolution efficiency between the reference product and Brands II, III and IV and in Mean dissolution time between the reference product and Brands II, III, IV and V. Using fit factors, only Brands I and III were similar. It has been demonstrated in vivo bioequivalence of furosemide market products interchangeability with generics should be avoided.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
BP International  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Furosemide  
dc.subject
Tablets  
dc.subject
Dissolution profiles  
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Commercial products  
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Model dependent  
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Model Independent  
dc.subject.classification
Otras Ciencias de la Salud  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
A Comparative Analysis of Dissolution Profiles of Furosemide Tablets Available in the Argentinean Market (Part 2)  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.type
info:eu-repo/semantics/bookPart  
dc.type
info:ar-repo/semantics/parte de libro  
dc.date.updated
2021-12-03T20:37:11Z  
dc.journal.volume
9  
dc.journal.pagination
81-92  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Han, Yong Ki. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina  
dc.description.fil
Fil: Simionato, Laura Daniela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina  
dc.description.fil
Fil: Calvo, Romina Giselle. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina  
dc.description.fil
Fil: Mattei, M. Belén. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina  
dc.description.fil
Fil: Segall, Adriana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://stm.bookpi.org/CACB-V9/article/view/2200  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/ 10.9734/bpi/cacb/v9/2661F  
dc.conicet.paginas
143  
dc.source.titulo
Current Advances in Chemistry and Biochemistry