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dc.contributor.author
Terra, Ximena
dc.contributor.author
Auguet, Teresa
dc.contributor.author
Broch, Montserrat
dc.contributor.author
Sabench, Fátima
dc.contributor.author
Hernandez, Mercè
dc.contributor.author
Pastor, Rosa M.
dc.contributor.author
Quesada, Isabel María
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dc.contributor.author
Lunna, Ana
dc.contributor.author
Aguilar, Carmen
dc.contributor.author
Del Castillo, Daniel
dc.contributor.author
Richard, Cristobal
dc.date.available
2017-04-06T18:46:45Z
dc.date.issued
2013-01
dc.identifier.citation
Terra, Ximena; Auguet, Teresa; Broch, Montserrat; Sabench, Fátima; Hernandez, Mercè; et al.; Retinol binding Protein-4 circulating levels were higher in nonalcoholic fatty liver disease vs. histologically normal liver from morbidly obese women.; Nature Publishing Group; Obesity; 21; 1-2013; 170-177
dc.identifier.issn
1930-7381
dc.identifier.uri
http://hdl.handle.net/11336/14896
dc.description.abstract
We aimed to analyze the retinol binding protein-4 (RBP4) messenger RNA (mRNA) expression profiles in adipose tissues and liver of morbidly obese (MO) women with or without nonalcoholic fatty liver disease (NAFLD), and to study the relationships with other pro- and anti-inflammatory adipokines in vivo and in vitro. We performed a cross-sectional analysis of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT) and liver samples from four lean and 45 MO women with or without NAFLD by enzyme-linked immunosorbent assay and real-time reverse transcription-PCR. We also studied RBP4 expression in HepG2 hepatocytes under various inflammatory stimuli. Circulating RBP4 levels were higher in MO women, and specifically, in MO subjects with NAFLD compared with normal liver controls (lean and MO). RBP4 liver expression was higher in nonalcoholic steatohepatitis (NASH)-moderate/severe than in NASHmild. Overall RBP4 gene expression was higher in liver than in adipose tissues. Among them, the higher expression corresponded to SAT. VAT expression was lower in the MO cohort. In HepG2, RBP4 mRNA expression was reduced by tumor necrosis factor (TNF)-α and increased by adiponectin treatment. In conclusion, the results obtained in MO women with NAFLD, brings up the use of RBP4 and other adipokines as a panel of noninvasive molecular biomarkers when NAFLD is suspected. Further studies are needed with other obesity groups.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Nonalcoholic Fatty Liver Disease
dc.subject
Rbp-4
dc.subject
Obese
dc.subject
Adipokines
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Retinol binding Protein-4 circulating levels were higher in nonalcoholic fatty liver disease vs. histologically normal liver from morbidly obese women.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-09-19T18:47:00Z
dc.journal.volume
21
dc.journal.pagination
170-177
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Terra, Ximena. Universitat Rovira i Virgil. Departament de Medicina i Cirurgia; España
dc.description.fil
Fil: Auguet, Teresa. Universitat Rovira i Virgil. Departament de Medicina i Cirurgia; España. Hospital Universitari Joan XXIII. Servei Medicina Interna,; España
dc.description.fil
Fil: Broch, Montserrat. Universitat Rovira i Virgil. Departament de Medicina i Cirurgia; España
dc.description.fil
Fil: Sabench, Fátima. Hospital Sant Joan de Reus. Servei de Cirurgia,; España
dc.description.fil
Fil: Hernandez, Mercè. Hospital Sant Joan de Reus. Servei de Cirurgia,; España
dc.description.fil
Fil: Pastor, Rosa M.. Hospital Universitari Joan XXIII. Laboratori de Bioquímica; España
dc.description.fil
Fil: Quesada, Isabel María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universitat Rovira i Virgil. Departament de Medicina i Cirurgia; España
dc.description.fil
Fil: Lunna, Ana. Universitat Rovira i Virgil. Departament de Medicina i Cirurgia; España
dc.description.fil
Fil: Aguilar, Carmen. Universitat Rovira i Virgil. Departament de Medicina i Cirurgia; España
dc.description.fil
Fil: Del Castillo, Daniel. Hospital Sant Joan de Reus. Servei de Cirurgia, ; España
dc.description.fil
Fil: Richard, Cristobal. Universitat Rovira i Virgil. Departament de Medicina i Cirurgia; España. Hospital Universitari Joan XXIII. Servei Medicina Interna,; España
dc.journal.title
Obesity
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/oby.20233/pdf
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http:/dx.doi.org/10.1038/oby.2012.114
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