Artículo
Hazardous effects of urban air particulate matter acute exposure on lung and extrapulmonary organs in mice
Orona, Nadia Soledad
; Astort, Francisco
; Maglione, Guillermo Alberto; Ferraro, Sebastián Ariel
; Martin, Maximiliano Emanuel
; Morales, Celina; Mandalunis, Patricia Mónica; Brites, Fernando Daniel
; Tasat, Jose Alejandro
Fecha de publicación:
03/2020
Editorial:
Academic Press Inc Elsevier Science
Revista:
Ecotoxicology and Environmental Safety
ISSN:
0147-6513
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Air particulate matter (PM) can lead to extrapulmonary adverse reactions in organs such as liver and heart either by particle translocation from the lung to the systemic circulation or by the release of lung mediators. Young BALB/c mice were intranasal instilled with 1mg/BW of Urban Air Particles from Buenos Aires or Residual Oil Fly Ash. Histopathology, oxidative metabolism and inflammation on lungs and extrapulmonary organs and the systemic response were evaluated. Lung histophatological analysis supported the rise in the number of inflammatory cells in the bronchoalveolar lavage from PM-exposed animals. Also, both PM caused recruitment of inflammatory cells in the liver and heart parenchyma and IL-6 and transaminases augmentation in serum. We have shown that despite morphochemical differences, both urban air PM altered the lung and extrapulmonary organs. Therefore, exposure to urban air PM may distress body metabolism which, in turn could lead to the development and progression of multifactorial diseases.
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Articulos(IIB-INTECH)
Articulos de INST.DE INVEST.BIOTECNOLOGICAS - INSTITUTO TECNOLOGICO CHASCOMUS
Articulos de INST.DE INVEST.BIOTECNOLOGICAS - INSTITUTO TECNOLOGICO CHASCOMUS
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Orona, Nadia Soledad; Astort, Francisco; Maglione, Guillermo Alberto; Ferraro, Sebastián Ariel; Martin, Maximiliano Emanuel; et al.; Hazardous effects of urban air particulate matter acute exposure on lung and extrapulmonary organs in mice; Academic Press Inc Elsevier Science; Ecotoxicology and Environmental Safety; 190; 3-2020; 1-11
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