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dc.contributor.author
Ciapponi, Agustín
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dc.date.available
2021-12-09T10:14:50Z
dc.date.issued
2019-11
dc.identifier.citation
Ciapponi, Agustín; How do effects of active nicotine replacement therapy (NRT) differ across different genetic biomarkers for people trying to quit smoking?; Wiley; Cochrane Clinical Answers; 11-2019; 1-16
dc.identifier.issn
2050-4217
dc.identifier.uri
http://hdl.handle.net/11336/148441
dc.description.abstract
For people trying to quit smoking, NRT may be more beneficial for some genetic subgroups like rs1051730, NMR, rs588765, or DRD4 (exon 3 48 bp), although the increase in absolute numbers of people quitting is low for all subgroups.The effects of NRT differ across different genetic biomarkers for people trying to quit smoking. Moderate‐certainty evidence indicates a positive effect of NRTs on six‐month and end of treatment abstinence for rs1051730 non‐Hispanic white people (differences of 101 and 117 per 1000 people, respectively; all results on average), on nicotine/metabolite ratio (NMR) subgroups (differences of 64 and 87 per 1000 people), and on end of treatment abstinence for rs16969968 and rs588765 non‐Hispanic white people (differences of 99 and 72 per 1000 people, respectively).Low‐certainty evidence suggests a more positive effect of NRTs for the DRD4 (exon 3 48 bp) non‐Hispanic white subgroup on six‐month abstinence (difference of 61 per 1000 people). Low‐ to moderate‐certainty evidence yielded imprecise results for abstinence at six months and at end of treatment for rs16969968 and rs2036527 subgroups. The reviewers did not assess adverse events.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
SALUD
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
How do effects of active nicotine replacement therapy (NRT) differ across different genetic biomarkers for people trying to quit smoking?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-01-04T14:29:52Z
dc.journal.pagination
1-16
dc.journal.pais
Reino Unido
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dc.description.fil
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
dc.journal.title
Cochrane Clinical Answers
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1002/cca.2810
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/cca.2810
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