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dc.contributor.author
Chen, Yuchao  
dc.contributor.author
Kuang, Yi  
dc.contributor.author
Shi, Liyang  
dc.contributor.author
Wang, Xing  
dc.contributor.author
Fu, Haoyu  
dc.contributor.author
Yang, Shengxiang  
dc.contributor.author
Sampietro, Diego Alejandro  
dc.contributor.author
Huang, Luqi  
dc.contributor.author
Yuan, Yuan  
dc.date.available
2021-12-07T14:21:49Z  
dc.date.issued
2021-09  
dc.identifier.citation
Chen, Yuchao; Kuang, Yi; Shi, Liyang; Wang, Xing; Fu, Haoyu; et al.; Synthesis and Evaluation of New Halogenated GR24 Analogs as Germination Promotors for Orobanche cumana; Frontiers Media S.A.; Frontiers in Plant Science; 12; 9-2021; 1-9  
dc.identifier.issn
1664-462X  
dc.identifier.uri
http://hdl.handle.net/11336/148378  
dc.description.abstract
Orobanche and Striga are parasitic weeds extremely well adapted to the life cycle of their host plants. They cannot be eliminated by conventional weed control methods. Suicidal germination induced by strigolactones (SLs) analogs is an option to control these weeds. Here, we reported two new halogenated (+)-GR24 analogs, named 7-bromo-GR24 (7BrGR24) and 7-fluoro-GR24 (7FGR24), which were synthesized using commercially available materials following simple steps. Both compounds strongly promoted seed germination of Orobanche cumana. Their EC50 values of 2.3±0.28×10−8M (7BrGR24) and 0.97±0.29×10−8M (7FGR24) were 3- and 5-fold lower, respectively, than those of (+)-GR24 and rac-GR24 (EC50=5.1±1.32–5.3±1.44×10−8; p<0.05). The 7FGR24 was the strongest seed germination promoter tested, with a stimulation percentage of 62.0±9.1% at 1.0×10−8M and 90.9±3.8% at 1.0×10−6M. It showed higher binding affinity (IC50=0.189±0.012μM) for the SL receptor ShHTL7 than (+)-GR24 (IC50=0.248±0.032μM), rac-GR24 (IC50=0.319±0.032μM), and 7BrGR24 (IC50=0.521±0.087μM). Molecular docking experiments indicated that the binding affinity of both halogenated analogs to the strigolactone receptor OsD14 was similar to that of (+)-GR24. Our results indicate that 7FGR24 is a promising agent for the control of parasitic weeds.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Frontiers Media S.A.  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
GR24 ANALOGS  
dc.subject
OROBANCHE CUMANA  
dc.subject
PARASITIC WEEDS  
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STRIGOLACTONES  
dc.subject
SUICIDAL GERMINATION  
dc.subject.classification
Biotecnología Agrícola y Biotecnología Alimentaria  
dc.subject.classification
Biotecnología Agropecuaria  
dc.subject.classification
CIENCIAS AGRÍCOLAS  
dc.title
Synthesis and Evaluation of New Halogenated GR24 Analogs as Germination Promotors for Orobanche cumana  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-12-03T20:11:00Z  
dc.journal.volume
12  
dc.journal.pagination
1-9  
dc.journal.pais
Suiza  
dc.journal.ciudad
Lausana  
dc.description.fil
Fil: Chen, Yuchao. Anhui University Of Chinese Medicine; China  
dc.description.fil
Fil: Kuang, Yi. Zhejiang A&f University; China  
dc.description.fil
Fil: Shi, Liyang. Zhejiang A&f University; China  
dc.description.fil
Fil: Wang, Xing. Zhejiang A&f University; China  
dc.description.fil
Fil: Fu, Haoyu. Zhejiang A&f University; China  
dc.description.fil
Fil: Yang, Shengxiang. Zhejiang A&f University; China  
dc.description.fil
Fil: Sampietro, Diego Alejandro. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales. Cátedra de Fitoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina  
dc.description.fil
Fil: Huang, Luqi. Anhui University Of Chinese Medicine; China  
dc.description.fil
Fil: Yuan, Yuan. China Academy Of Chinese Medical Sciences; China  
dc.journal.title
Frontiers in Plant Science  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fpls.2021.725949/full  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fpls.2021.725949