Capítulo de Libro
Comparative analysis of hydrogen peroxide and peroxynitrite reactivity with thiols
Título del libro: Hydrogen peroxide metabolism in health and disease
Fecha de publicación:
2017
Editorial:
CRC Press; Taylor&Francis
ISBN:
9781498776158
Idioma:
Inglés
Clasificación temática:
Resumen
Peroxides are chemical compounds in which two oxygen atoms are linked together by a single covalent bond. Hydrogen peroxide (H2O2), the simplest peroxide, is formed through different routes in biological systems: superoxide radical (O2•-) dismutation, which can be spontaneous, or, depending on the organism and cellular compartment, catalyzed by different superoxide dismutases (SODs); one-electron O2•- reduction, such as during aconitase oxidation; or direct two-electron reduction of oxygen, which can be catalyzed by the divalent activity of several oxidases, including xanthine oxidase, Ero1, aldehyde oxidase, and monoamine oxidase. Depending on the cell type, those sites could be mitochondria, phagosomes of inflammatory cells, as well as the extracellular space. In biological systems, thiol functional groups can be found as part of low-molecular-weight (LMW) compounds and in protein Cys residues. Most living organisms contain millimolar concentrations of LMW thiols that play biological functions, such as to keep an intracellular reducing environment, to provide electrons for redox enzymes, and to react with electrophilic compounds.
Palabras clave:
Hydrogen Peroxide
,
Peroxynitrite
,
Reactivity
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Capítulos de libros(INQUIMAE)
Capítulos de libros de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Capítulos de libros de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Citación
Trujillo, Madia; Carballal, Sebastian; Zeida Camacho, Ari Fernando; Radi, Rafael; Comparative analysis of hydrogen peroxide and peroxynitrite reactivity with thiols; CRC Press; Taylor&Francis; 2017; 49-80
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