Artículo
Whole genome analysis of the action of interferon-β
Kauffman, Marcelo Andres
; Yankilevich, Patricio
; Barrero, Paola Roxana
; Ricardo Bello; Marangunich, L.; Vidal, A.; Criscuolo, M.; Diez, Roberto Alejandro; Sterin Prync, Aída Edith
Fecha de publicación:
05/2009
Editorial:
Dustri-Verlag Dr. Karl Feistle
Revista:
International Journal of Clinical Pharmacology and Therapeutics
ISSN:
0946-1965
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Objectives: To characterize the IFN1a-regulated gene expression on leukocytes of Multiple Sclerosis (MS) patients using microarrays with whole human genome representation. Methods: Genes differentially expressed by interferon- were identified by a microarray in vitro study performed in leukocytes obtained from 5MS relapsing-remitting patients. Results: Following the culture of peripheral blood mononuclear cells from MS relapsing-remitting patients for 24 hs with IFN1a, the expression of 868 genes was modified: 545 increased (including CXCL11, CCL8, INDO, IFI27, CFB, CXCL10 and IFIT1) and 323 diminished (including RBP7, SEPT5, RNF8, ADORA2B and FOS). Conclusions: Since many of them were previously recognized as involved in MS pathogenesis, the IFNb1a mechanism of action could imply a compensatory regulation of systems deregulated in MS.
Palabras clave:
GENOMICS
,
INTERFERON-Β
,
MICROARRAY
,
MULTIPLE SCLEROSIS
,
TREATMENT
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Colecciones
Articulos(IBCN)
Articulos de INST.DE BIOLO.CEL.Y NEURCS."PROF.E.DE ROBERTIS"
Articulos de INST.DE BIOLO.CEL.Y NEURCS."PROF.E.DE ROBERTIS"
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Kauffman, Marcelo Andres; Yankilevich, Patricio; Barrero, Paola Roxana; Ricardo Bello; Marangunich, L.; et al.; Whole genome analysis of the action of interferon-β; Dustri-Verlag Dr. Karl Feistle; International Journal of Clinical Pharmacology and Therapeutics; 47; 5; 5-2009; 328-357
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