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dc.contributor.author
Sisti, María Susana
dc.contributor.author
Nishida, Fabian
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Zanuzzi, Carolina Natalia
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Laurella, Sergio Luis
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Cantet, Rodolfo Juan Carlos
dc.contributor.author
Portiansky, Enrique Leo
dc.date.available
2021-12-02T14:27:34Z
dc.date.issued
2019-04-17
dc.identifier.citation
Sisti, María Susana; Nishida, Fabian; Zanuzzi, Carolina Natalia; Laurella, Sergio Luis; Cantet, Rodolfo Juan Carlos; et al.; Lidocaine protects neurons of the spinal cord in an excitotoxicity model; Elsevier Ireland; Neuroscience Letters; 698; 17-4-2019; 105-112
dc.identifier.issn
0304-3940
dc.identifier.uri
http://hdl.handle.net/11336/147951
dc.description.abstract
Motor Neuron Disease disorders, described in domestic animals, are characterized by neuronal degeneration at the spinal cord. Excitotoxicity is a crucial factor for the selective loss of these neurons, being the fundamental processes involved in lesion progression after spinal cord injury, where glutamate is one of the main neurotransmitters involved. Kainic acid (KA) resembles the effects induced by the pathological release of glutamate. Lidocaine administered by different routes exerts some neuroprotective effects in the CNS. The aim of the present work was to determine whether lidocaine simultaneously injected with KA into the spinal cord could prevent the excitotoxic effects of the latter. Sprague-Dawley rats were injected by intraparenchymal route with KA or with KA plus 0.5% lidocaine into the C5 segment. Sham rats were injected with saline. Animals were motor and sensory tested at 0, 1, 2, 3, 7 and 14 post-injection days and then euthanized. Sections of the C5 segment were used for histological and immunohistochemical analysis. No KA-induced motor and sensitive impairments were observed when lidocaine was simultaneously injected with KA. Moreover, neuronal counting was statistically higher when compared with KA-injected animals. Thus, lidocaine could be considered as a neuroprotective drug in diseases and models involving excitotoxicity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Excitotoxicity
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Kainic acid
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Lidocaine
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Spinal cord injury
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Excitotoxicity
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Lidocaine
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Lidocaine protects neurons of the spinal cord in an excitotoxicity model
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-19T15:48:54Z
dc.identifier.eissn
1872-7972
dc.journal.volume
698
dc.journal.pagination
105-112
dc.journal.pais
Irlanda
dc.description.fil
Fil: Sisti, María Susana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.description.fil
Fil: Nishida, Fabian. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.description.fil
Fil: Zanuzzi, Carolina Natalia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.description.fil
Fil: Laurella, Sergio Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
dc.description.fil
Fil: Cantet, Rodolfo Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Unidad Ejecutora de Investigaciones en Producción Animal. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Unidad Ejecutora de Investigaciones en Producción Animal; Argentina
dc.description.fil
Fil: Portiansky, Enrique Leo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.journal.title
Neuroscience Letters
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0304394019300254
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.neulet.2019.01.019
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