Mostrar el registro sencillo del ítem
dc.contributor.author
Calzado, Enaide Maine
dc.contributor.author
Rodríguez, Jorge Luis García
dc.contributor.author
Bergues Cabrales, Luis Enrique
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Monier García, Francisco
dc.contributor.author
Selva Castañeda, Antonio Rafael
dc.contributor.author
González Delgado, Ivelice María
dc.contributor.author
Mesa Torres, Leonardo
dc.contributor.author
Giró Uribazo, Fidel Valentín
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Morales González, Maraelys
dc.contributor.author
Acosta Brooks, Soraida Candida
dc.contributor.author
Rubio González, Tamara
dc.contributor.author
Roca Oria, Eduardo José
dc.contributor.author
Bravo Roger, Leonardo Lorenzo
dc.contributor.author
Hernández Figueroa, Hugo Enrique
dc.contributor.author
Pérez, Geisa Dávila
dc.date.available
2021-12-01T13:47:23Z
dc.date.issued
2019-12
dc.identifier.citation
Calzado, Enaide Maine; Rodríguez, Jorge Luis García; Bergues Cabrales, Luis Enrique; Monier García, Francisco; Selva Castañeda, Antonio Rafael; et al.; Simulations of the electrostatic field, temperature, and tissue damage generated by multiple electrodes for electrochemical treatment; Elsevier Science Inc; Applied Mathematical Modelling; 76; 12-2019; 699-716
dc.identifier.issn
0307-904X
dc.identifier.uri
http://hdl.handle.net/11336/147846
dc.description.abstract
Integrated analysis of the spatial distributions of the electric potential, electric field, temperature, and tissue damage generated by multiple arrays of straight needle electrodes inserted into tumors is highly significant for improving the effectiveness of electrochemical treatment. In this study, we simulated the spatial profiles generated by multiple electrodes inserted individually into a tumor and multiple pairs of straight needle electrodes inserted in a tumor surrounded by healthy tissue. Poisson nonlinear and Laplace equations were used to calculate the electric potential in the tumor and the surrounding healthy tissue, respectively. The stationary bioheat transfer equation of Pennes was used to calculate the temperature in both tissues. The percentage tissue damage was computed in each biological medium for each electrode array shape. Numerical simulations showed that the non-homogeneous spatial distributions of the temperature (above 40 °C) generated by different types of multiple pairs of straight needle electrodes covered the whole tumor volume. Spatial profiles of this physical magnitude were generated by multiple straight needle electrodes, which were individually inserted into the tumor and partially covered by its volume. In addition, the simulations showed that multiple pairs of electrodes led to tumor damage percentages above 80%. By contrast, multiple electrodes inserted individually in the tumor induced damage percentages below 25%. We conclude that multiple pairs of straight needle electrodes may be applied to deep-seated solid tumors in treatment with electrochemical therapy considering their theoretically calculated high tumor damage percentages.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ELECTRIC FIELD
dc.subject
ELECTRIC POTENTIAL
dc.subject
ELECTROCHEMICAL THERAPY
dc.subject
ELECTRODE ARRAY
dc.subject
TEMPERATURE
dc.subject
TUMOR DAMAGE PERCENTAGE
dc.subject.classification
Otras Matemáticas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Matemáticas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Simulations of the electrostatic field, temperature, and tissue damage generated by multiple electrodes for electrochemical treatment
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-25T16:10:31Z
dc.journal.volume
76
dc.journal.pagination
699-716
dc.journal.pais
Estados Unidos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.description.fil
Fil: Calzado, Enaide Maine. Universidad de Oriente; Cuba
dc.description.fil
Fil: Rodríguez, Jorge Luis García. Universidad de Oriente; Cuba
dc.description.fil
Fil: Bergues Cabrales, Luis Enrique. Universidad de Oriente; Cuba
dc.description.fil
Fil: Monier García, Francisco. Universidad de Oriente; Cuba
dc.description.fil
Fil: Selva Castañeda, Antonio Rafael. Universidad de Oriente; Cuba
dc.description.fil
Fil: González Delgado, Ivelice María. Universidad de Oriente; Cuba
dc.description.fil
Fil: Mesa Torres, Leonardo. Universidad de Oriente; Cuba
dc.description.fil
Fil: Giró Uribazo, Fidel Valentín. Universidad de Oriente; Cuba. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
dc.description.fil
Fil: Morales González, Maraelys. Universidad de Oriente; Cuba
dc.description.fil
Fil: Acosta Brooks, Soraida Candida. Hospital Provincial Saturnino Lora. Servicio de Medicina Interna; Cuba
dc.description.fil
Fil: Rubio González, Tamara. Dirección Municipal de Salud Pública. Servicio de Genética; Cuba
dc.description.fil
Fil: Roca Oria, Eduardo José. Universidad de Oriente; Cuba
dc.description.fil
Fil: Bravo Roger, Leonardo Lorenzo. Universidade Estadual de Campinas; Brasil
dc.description.fil
Fil: Hernández Figueroa, Hugo Enrique. Universidade Estadual de Campinas; Brasil
dc.description.fil
Fil: Pérez, Geisa Dávila. Universidad de Oriente; Cuba
dc.journal.title
Applied Mathematical Modelling
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.apm.2019.05.002
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0307904X19302859
Archivos asociados