How does eszopiclone compare with placebo for adults with insomnia?

Abstract

Moderate‐certainty evidence shows that adults with primary insomnia taking eszopiclone 2 to 3 mg daily fell asleep a mean of 12 minutes more quickly and woke up a mean of 17 minutes later aer onset of persistent sleep than those taking placebo (follow‐up two days to six months). There was little or no dierence between groups in withdrawal symptoms (accidental injury, agitation, anxiety, back pain, dizziness, headache, nausea, pharyngitis, and pain) or in rebound insomnia. Eszopiclone increased total sleep time (a mean of around 30 minutes more; moderate‐certainty evidence) and slightly improved next‐day alertness (mean dierence of 0.46 points on a scale from 0 to 10; low‐certainty evidence).