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dc.contributor.author
Schmidt, André
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Dias Romano, Minna Moreira
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Marin Neto, José Antônio
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Rao Melacini, Purnima
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Rassi, Anis
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Mattos, Antônio
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Avezum, Álvaro
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Villena, Erick
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Sosa-Estani, Sergio Alejandro
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Bonilla, Rina
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Yusuf, Salim
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Morillo, Carlos A.
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Maciel, Benedito Carlos
dc.date.available
2021-11-30T15:58:13Z
dc.date.issued
2019-02
dc.identifier.citation
Schmidt, André; Dias Romano, Minna Moreira; Marin Neto, José Antônio; Rao Melacini, Purnima; Rassi, Anis; et al.; Effects of Trypanocidal Treatment on Echocardiographic Parameters in Chagas Cardiomyopathy and Prognostic Value of Wall Motion Score Index: A BENEFIT Trial Echocardiographic Substudy; Mosby-Elsevier; Journal Of The American Society Of Echocardiography : Official Publication Of The American Society Of Echocardiography.; 32; 2; 2-2019; 286-295.e3
dc.identifier.issn
0894-7317
dc.identifier.uri
http://hdl.handle.net/11336/147740
dc.description.abstract
Background: Serial echocardiographic studies in chronic Chagas cardiomyopathy are scarce. The aims of this study were to evaluate whether therapy with benznidazole modifies the progression of cardiac impairment and to identify baseline echocardiographic parameters related to prognosis. Methods: A prospective substudy was conducted in 1,508 patients with chronic Chagas cardiomyopathy randomized to benznidazole or placebo, who underwent two-dimensional echocardiography at enrollment, 2 years, and final follow-up (5.4 years). Left ventricular (LV) ejection fraction, LV wall motion score index (WMSI), indexed left atrial volume, and chamber dimensions were collected and correlated to all-cause death and a composite hard outcome using univariate and multivariate analyses. Results: At enrollment, most patients had normal chamber dimensions, and 70.5% had preserved LV ejection fractions. During follow-up, all chamber dimensions increased similarly in both treatment arms. LV ejection fraction was comparably reduced (55.7 ± 12.7% to 52.1 ± 14.6% vs 56.3 ± 12.7% to 52.8 ± 14.1%) and LV WMSI similarly increased (1.31 ± 0.41 to 1.49 ± 0.03 and 1.27 ± 0.38 to 1.51 ± 0.03) for the benznidazole and placebo groups, respectively (P >.05). A higher baseline LV WMSI was identified in subjects who died compared with those alive at final echocardiography (1.76 ± 0.517 vs 1.271 ± 0.393, P <.0001). There was a significant (P <.0001) graded increase in the risk for the composite outcome with worsening LV WMSI (hazard ratios, 2.27 [95% CI, 1.69–3.06] and 6.42 [95% CI, 4.94–8.33]) and also of death (hazard ratios, 2.45 [95% CI, 1.62–3.71] and 8.99 [95% CI, 6.3–12.82]) for 1 < LV WMSI < 1.5 and LV WMSI > 1.5, respectively. Both LV WMSI and indexed left atrial volume remained independent predictors in multivariate analysis. Conclusions: Trypanocidal treatment had no effect on echocardiographic progression of chronic Chagas cardiomyopathy over 5.4 years. Despite normal global LV systolic function, regional wall motion abnormalities and indexed left atrial volume identified patients at higher risk for hard adverse clinical outcomes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Mosby-Elsevier
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CHAGAS CARDIOMYOPATHY
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ECHOCARDIOGRAPHY
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PROGNOSIS
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TRYPANOCIDAL THERAPY
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Sistemas Cardíaco y Cardiovascular
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Effects of Trypanocidal Treatment on Echocardiographic Parameters in Chagas Cardiomyopathy and Prognostic Value of Wall Motion Score Index: A BENEFIT Trial Echocardiographic Substudy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-01-04T14:32:16Z
dc.journal.volume
32
dc.journal.number
2
dc.journal.pagination
286-295.e3
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Schmidt, André. Universidade de Sao Paulo; Brasil
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Fil: Dias Romano, Minna Moreira. Universidade de Sao Paulo; Brasil
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Fil: Marin Neto, José Antônio. Universidade de Sao Paulo; Brasil
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Fil: Rao Melacini, Purnima. Hamilton Health Sciences; Canadá
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Fil: Rassi, Anis. Hospital Do Coração Anis Rassi; Brasil
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Fil: Mattos, Antônio. Instituto Dante Pazzanese de Cardiologia; Brasil
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Fil: Avezum, Álvaro. Instituto Dante Pazzanese de Cardiologia; Brasil
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Fil: Villena, Erick. Hospital Eduardo Eguia; Bolivia
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Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
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Fil: Bonilla, Rina. Hospital Nacional Rosales; El Salvador
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Fil: Yusuf, Salim. Hamilton Health Sciences; Canadá
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Fil: Morillo, Carlos A.. Hamilton Health Sciences; Canadá
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Fil: Maciel, Benedito Carlos. Universidade de Sao Paulo; Brasil
dc.journal.title
Journal Of The American Society Of Echocardiography : Official Publication Of The American Society Of Echocardiography.
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.echo.2018.09.006
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info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0894731718305042
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