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dc.contributor.author
Ciapponi, Agustín
dc.date.available
2021-11-30T13:58:05Z
dc.date.issued
2019-10
dc.identifier.citation
Ciapponi, Agustín; What are the effects of pregabalin add-on for people with drug-resistant focal epilepsy?; Wiley; Cochrane Clinical Answers; 10-2019; 1-14
dc.identifier.issn
2050-4217
dc.identifier.uri
http://hdl.handle.net/11336/147714
dc.description.abstract
Compared with placebo for adolescents and adults with drug‐resistant focal epilepsy taking up to five antiepileptic drugs (AEDs), low‐certainty evidence suggests that more people may achieve a 50% or greater reduction in seizure frequency with pregabalin within 12 to 17 weeks (319 vs 140 per 1000 people; all results on average). Moderate‐certainty evidence shows that more people will probably be seizure‐free with pregabalin, although the absolute numbers of people benefiting are likely to be small (28 vs 7 per 1000 people). Moderate‐certainty evidence also shows that more people taking pregabalin are likely to withdraw from treatment (for any reason or due to an adverse effect; 47 and 102 additional withdrawals per 1000 people, respectively) and/or to experience ataxia, dizziness, somnolence, and weight gain (89, 193, 95, and 82 additional events per 1000 people).
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
SALUD
dc.subject.classification
Otras Ciencias de la Salud
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
What are the effects of pregabalin add-on for people with drug-resistant focal epilepsy?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-01-04T14:28:26Z
dc.journal.pagination
1-14
dc.journal.pais
Argentina
dc.description.fil
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
dc.journal.title
Cochrane Clinical Answers
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1002/cca.2301
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/cca.2301
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