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dc.contributor.author
Welker, Frido
dc.contributor.author
Collins, Matthew J.
dc.contributor.author
Thomas, Jessica A.
dc.contributor.author
Wadsley, Marc
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Brace, Selina
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Cappellini, Enrico
dc.contributor.author
Turvey, Samuel T.
dc.contributor.author
Reguero, Marcelo Alfredo
dc.contributor.author
Gelfo, Javier Nicolás
dc.contributor.author
Kramarz, Alejandro Gustavo
dc.contributor.author
Burger, Joachim
dc.contributor.author
Thomas Oates, Jane
dc.contributor.author
Ashford, David A.
dc.contributor.author
Ashton, Peter D.
dc.contributor.author
Rowsell, Keri
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Porter, Duncan M.
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Kessler, Benedikt
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Fischer, Roman
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Baessmann, Carsten
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Kaspar, Stephanie
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Olsen, Jesper V.
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Kiley, Patrick
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Elliot, James A.
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Kelstrup, Christian D.
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Mullin, Victoria
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Hofreiter, Michael
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Willerslev, Eske
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Hublin, Jean Jacques
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Orlando, Ludovic
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Barnes, Ian
dc.contributor.author
MacPhee, Ross D. E.
dc.date.available
2017-04-03T21:46:15Z
dc.date.issued
2015-06
dc.identifier.citation
Welker, Frido; Collins, Matthew J.; Thomas, Jessica A.; Wadsley, Marc; Brace, Selina; et al.; Ancient proteins resolve the evolutionary history of Darwin’s South American ungulates; Nature Publishing Group; Nature; 522; 7554; 6-2015; 81-84
dc.identifier.issn
0028-0836
dc.identifier.uri
http://hdl.handle.net/11336/14769
dc.description.abstract
No large group of recently extinct placental mammals remains as evolutionarily cryptic as the approximately 280 genera grouped as ‘South American native ungulates’. To Charles Darwin1,2, who first collected their remains, theyincluded perhaps the ‘strangest animal[s] ever discovered’. Today, much like 180 years ago, it is no clearer whether they had one origin or several, arose before or after the Cretaceous/Palaeogene transition 66.2 million years ago3 , or are more likely to belong with the elephants and sirenians of superorder Afrotheria than with the euungulates (cattle, horses, and allies) of superorder Laurasiatheria4–6.Morphology-based analyses have proved unconvincing because convergences are pervasive among unrelated ungulate-like placentals. Approaches using ancient DNA have also been unsuccessful, probably because of rapid DNA degradation in semitropical and temperate deposits. Here we apply proteomic analysis to screen bone samples of the Late Quaternary South American native ungulate taxa Toxodon (Notoungulata) and Macrauchenia (Litopterna) for phylogeneticallyinformative protein sequences. For each ungulate, we obtain approximately 90% direct sequence coverage of type I collagena1- anda2-chains, representing approximately 900 of 1,140 amino-acid residues for each subunit. A phylogeny is estimated from an alignment of these fossil sequences with collagen (I) gene transcripts from availablemammalian genomes ormass spectrometrically derived sequence data obtained for this study. The resulting consensus tree agrees well with recent higher-level mammalian phylogenies7–9. Toxodon and Macrauchenia form a monophyletic group whose sister taxon is not Afrotheria or any of its constituent clades as recently claimed5,6, but instead crown Perissodactyla (horses, tapirs, and rhinoceroses). These results are consistent with the origin of at least some South American native ungulates4,6 from ‘condylarths’, a paraphyletic assembly of archaic placentals. With ongoing improvements in instrumentation and analytical procedures, proteomics may produce a revolution in systematics such as that achieved by genomics, but with the possibility of reaching much further back in time.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Mammalia
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Phylogeny
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Collagen (I)
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Notoungulata
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Litopterna
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Laurasiatheria
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Paleontología
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Ciencias de la Tierra y relacionadas con el Medio Ambiente
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CIENCIAS NATURALES Y EXACTAS
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Genética y Herencia
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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Biología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Ancient proteins resolve the evolutionary history of Darwin’s South American ungulates
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-08T15:40:21Z
dc.identifier.eissn
1476-4687
dc.journal.volume
522
dc.journal.number
7554
dc.journal.pagination
81-84
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Welker, Frido. University Of York; Reino Unido. Institut Max Planck For Evolutionary Anthropology; Alemania
dc.description.fil
Fil: Collins, Matthew J.. University Of York; Reino Unido
dc.description.fil
Fil: Thomas, Jessica A.. University Of York; Reino Unido
dc.description.fil
Fil: Wadsley, Marc. University Of York; Reino Unido
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Fil: Brace, Selina. Natural History Museum; Reino Unido
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Fil: Cappellini, Enrico. Natural History Museum; Dinamarca
dc.description.fil
Fil: Turvey, Samuel T.. The Zoological Society Of London; Reino Unido
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Fil: Reguero, Marcelo Alfredo. Universidad Nacional de la Plata. Facultad de Ciencias Naturales y Museo. División Paleontología Vertebrados; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Gelfo, Javier Nicolás. Universidad Nacional de la Plata. Facultad de Ciencias Naturales y Museo. División Paleontología Vertebrados; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Kramarz, Alejandro Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales; Argentina
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Fil: Burger, Joachim. Johannes Gutenberg University; Alemania
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Fil: Thomas Oates, Jane. University Of York; Reino Unido
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Fil: Ashford, David A.. University Of York; Reino Unido
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Fil: Ashton, Peter D.. University Of York; Reino Unido
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Fil: Rowsell, Keri. University Of York; Reino Unido
dc.description.fil
Fil: Porter, Duncan M.. Virginia Polytechnic Institute; Estados Unidos
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Fil: Kessler, Benedikt. University of Oxford; Reino Unido
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Fil: Fischer, Roman. University of Oxford; Reino Unido
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Fil: Baessmann, Carsten. Bruker Daltonik; Alemania
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Fil: Kaspar, Stephanie. Bruker Daltonik; Alemania
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Fil: Olsen, Jesper V.. Universidad de Copenhagen; Dinamarca
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Fil: Kiley, Patrick. University of Cambridge; Reino Unido
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Fil: Elliot, James A.. University of Cambridge; Reino Unido
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Fil: Kelstrup, Christian D.. Universidad de Copenhagen; Dinamarca
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Fil: Mullin, Victoria. Trinity College Dublin; Irlanda
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Fil: Hofreiter, Michael. University Of York; Reino Unido. Institute for Biochemistry and Biology; Alemania
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Fil: Willerslev, Eske. Natural History Museum; Dinamarca
dc.description.fil
Fil: Hublin, Jean Jacques. Institut Max Planck For Evolutionary Anthropology; Alemania
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Fil: Orlando, Ludovic. Natural History Museum; Dinamarca
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Fil: Barnes, Ian. Natural History Museum; Reino Unido
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Fil: MacPhee, Ross D. E.. American Museum Of Natural History; Estados Unidos
dc.journal.title
Nature
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/nature14249
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/nature/journal/v522/n7554/full/nature14249.html
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