Artículo
M1 macrophage polarization prevails in EBV infected children in an immuneregulatory environment
Moyano, Agustina Ayelén
; Ferressini Gerpe, Natalia Marina
; de Matteo, Elena Noemí
; Preciado, Maria Victoria
; Chabay, Paola Andrea
Fecha de publicación:
29/10/2021
Editorial:
American Society for Microbiology
Revista:
Journal of Virology
ISSN:
0022-538X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Macrophages can be polarized toward a proinflammatory phenotype (M1) (CD68+) or to an anti-inflammatory one (M2) (CD163+). Polarization can be triggered by cytokines such as IFN-γ for M1, or IL-10 and TGF-β, for M2. In the context of pediatric EBV infection, little is known about macrophage polarization in EBV primary or persistent infection. When studying tonsils of patients undergoing primary infection (PI), healthy carrier (HC), reactivation (R) and not infected (NI), M1 profile prevailed in all infection status. However, an increase in M2 cells was observed in those patients with broader expression of latency antigens, in particular EBNA2. Tonsils from primary infected patients showed an increased IL-10 expression, whereas, unexpectedly, TGF-β expression correlated with M1 marker. Furthermore, an inverse correlation was demonstrated between CD68 and IFN-γ. Therefore, in the context of asymptomatic infection in children, M1 macrophage polarization prevails, even in the presence of IL-10 and TGF-b immunomodulatory cytokines, and it might be independent from lymphomagenesis process. Our finding indicates that macrophages may have a significant plasticity in response to different types of extrinsic stimuli, and further studies are required to investigate M1 polarization under anti-inflammatory stimuli.
Palabras clave:
EPSTEIN BARR VIRUS
,
MACROPHAGE
,
POLARIZATION
,
CHILDREN
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Articulos(IMIPP)
Articulos de INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES EN PATOLOGIAS PEDIATRICAS
Articulos de INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES EN PATOLOGIAS PEDIATRICAS
Citación
Moyano, Agustina Ayelén; Ferressini Gerpe, Natalia Marina; de Matteo, Elena Noemí; Preciado, Maria Victoria; Chabay, Paola Andrea; M1 macrophage polarization prevails in EBV infected children in an immuneregulatory environment; American Society for Microbiology; Journal of Virology; 29-10-2021; 1-12
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