Artículo
Study of the lamellar and micellar phases of pluronic F127: A molecular dynamics approach
Albano, Juan Manuel Ricardo
; Grillo, Damián Alexis
; Facelli, Julio C.; Ferraro, Marta Beatriz
; Pickholz, Mónica Andrea
Fecha de publicación:
07/09/2019
Editorial:
Multidisciplinary Digital Publishing Institute
Revista:
Processes
ISSN:
2227-9717
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In this work, we analyzed the behavior of Pluronic F127 through molecular dynamics simulations at the coarse-grain level, focusing on the micellar and lamellar phases. To this aim, two initial polymer conformations were considered, S-shape and U-shape, for both simulated phases. Through the simulations, we were able to examine the structural and mechanical properties that are difficult to access through experiments. Since no transition between S and U shapes was observed in our simulations, we inferred that all single co-polymers had memory of their initial configuration. Nevertheless, most copolymers had a more complex amorphous structure, where hydrophilic beads were part of the lamellar-like core. Finally, an overall comparison of the micellar a lamellar phases showed that the lamellar thickness was in the same order of magnitude as the micelle diameter (approx. 30 nm). Therefore, high micelle concentration could lead to lamellar formation. With this new information, we could understand lamellae as orderly packed micelles.
Palabras clave:
LAMELLAR
,
MICELLAR
,
MOLECULAR DYNAMICS
,
PLURONIC F127
,
POLOXAMER
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IFIBA)
Articulos de INST.DE FISICA DE BUENOS AIRES
Articulos de INST.DE FISICA DE BUENOS AIRES
Citación
Albano, Juan Manuel Ricardo; Grillo, Damián Alexis; Facelli, Julio C.; Ferraro, Marta Beatriz; Pickholz, Mónica Andrea; Study of the lamellar and micellar phases of pluronic F127: A molecular dynamics approach; Multidisciplinary Digital Publishing Institute; Processes; 7; 9; 7-9-2019; 1-11
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