Artículo
Mechanisms involved in the relationship between low calcium intake and high blood pressure
Villa Etchegoyen, Cecilia; Lombarte, Mercedes
; Matamoros, Natalia; Belizan, Jose
; Cormick, Gabriela
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Fecha de publicación:
05/2019
Editorial:
Molecular Diversity Preservation International
Revista:
Nutrients
ISSN:
2072-6643
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
There is increasing epidemiologic and animal evidence that a low calcium diet increases blood pressure. The aim of this review is to compile the information on the link between low calcium intake and blood pressure. Calcium intake may regulate blood pressure by modifying intracellular calcium in vascular smooth muscle cells and by varying vascular volume through the renin–angiotensin–aldosterone system. Low calcium intake produces a rise of parathyroid gland activity. The parathyroid hormone increases intracellular calcium in vascular smooth muscles resulting in vasoconstriction. Parathyroidectomized animals did not show an increase in blood pressure when fed a low calcium diet as did sham-operated animals. Low calcium intake also increases the synthesis of calcitriol in a direct manner or mediated by parathyroid hormone (PTH). Calcitriol increases intracellular calcium in vascular smooth muscle cells. Both low calcium intake and PTH may stimulate renin release and consequently angiotensin II and aldosterone synthesis. We are willing with this review to promote discussions and contributions to achieve a better understanding of these mechanisms, and if required, the design of future studies.
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Articulos(CIESP)
Articulos de CENTRO DE INVESTIGACIONES EN EPIDEMIOLOGIA Y SALUD PUBLICA
Articulos de CENTRO DE INVESTIGACIONES EN EPIDEMIOLOGIA Y SALUD PUBLICA
Citación
Villa Etchegoyen, Cecilia; Lombarte, Mercedes; Matamoros, Natalia; Belizan, Jose; Cormick, Gabriela; Mechanisms involved in the relationship between low calcium intake and high blood pressure; Molecular Diversity Preservation International; Nutrients; 11; 5; 5-2019; 1-16
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