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dc.contributor.author
Voorsluijs, V.
dc.contributor.author
Ponce Dawson, Silvina Martha
dc.contributor.author
De Decker, Y.
dc.contributor.author
Dupont, G.
dc.date.available
2021-11-26T14:49:33Z
dc.date.issued
2019-02
dc.identifier.citation
Voorsluijs, V.; Ponce Dawson, Silvina Martha; De Decker, Y.; Dupont, G.; Deterministic Limit of Intracellular Calcium Spikes; American Physical Society; Physical Review Letters; 122; 8; 2-2019; 1-6
dc.identifier.issn
0031-9007
dc.identifier.uri
http://hdl.handle.net/11336/147504
dc.description.abstract
In nonexcitable cells, global Ca2+ spikes emerge from the collective dynamics of clusters of Ca2+ channels that are coupled by diffusion. Current modeling approaches have opposed stochastic descriptions of these systems to purely deterministic models, while both paradoxically appear compatible with experimental data. Combining fully stochastic simulations and mean-field analyses, we demonstrate that these two approaches can be reconciled. Our fully stochastic model generates spike sequences that can be seen as noise-perturbed oscillations of deterministic origin, while displaying statistical properties in agreement with experimental data. These underlying deterministic oscillations arise from a phenomenological spike nucleation mechanism.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Physical Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CALCIUM
dc.subject
OSCILLATIONS
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SPIKES
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DETERMINISM
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Otras Ciencias Físicas
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Ciencias Físicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Deterministic Limit of Intracellular Calcium Spikes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-20T16:00:29Z
dc.journal.volume
122
dc.journal.number
8
dc.journal.pagination
1-6
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Voorsluijs, V.. Université Libre de Bruxelles; Bélgica
dc.description.fil
Fil: Ponce Dawson, Silvina Martha. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
dc.description.fil
Fil: De Decker, Y.. Université Libre de Bruxelles; Bélgica
dc.description.fil
Fil: Dupont, G.. Université Libre de Bruxelles; Bélgica
dc.journal.title
Physical Review Letters
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.aps.org/doi/10.1103/PhysRevLett.122.088101
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1103/PhysRevLett.122.088101
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