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dc.contributor.author
Méndez, Manuel
dc.contributor.author
Rossetti, Maria Victoria
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dc.contributor.author
Batlle, Alcira María del C.
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dc.contributor.author
Parera, Victoria Estela
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dc.date.available
2021-11-24T17:46:02Z
dc.date.issued
2005-03
dc.identifier.citation
Méndez, Manuel; Rossetti, Maria Victoria; Batlle, Alcira María del C.; Parera, Victoria Estela; The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population; Mosby-Elsevier; Journal of the American Academy of Dermatology; 52; 3 Pt 1; 3-2005; 417-424
dc.identifier.issn
0190-9622
dc.identifier.uri
http://hdl.handle.net/11336/147347
dc.description.abstract
Background: Inherited and environmental factors are implicated in the expression of porphyria cutanea tarda (PCT); the contribution of each factor depends on the population.Inherited and environmental factors are implicated in the expression of porphyria cutanea tarda (PCT); the contribution of each factor depends on the population. Objective: To provide a review of PCT cases diagnosed in Argentina over 24 years and evaluate the role of different precipitating factors in its pathogenesis.To provide a review of PCT cases diagnosed in Argentina over 24 years and evaluate the role of different precipitating factors in its pathogenesis. Methods: Plasma and urinary porphyrin levels and erythrocyte uroporphyrinogen decarboxylase (URO-D) activity were determined. Potential precipitating factors were identified in each patient. Additional tests for hepatitis C virus (HCV) and hemochromatosis gene mutations were carried out.Plasma and urinary porphyrin levels and erythrocyte uroporphyrinogen decarboxylase (URO-D) activity were determined. Potential precipitating factors were identified in each patient. Additional tests for hepatitis C virus (HCV) and hemochromatosis gene mutations were carried out. Results: Several factors (mainly alcohol abuse in men and estrogen ingestion in women), alone or combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.) Several factors (mainly alcohol abuse in men and estrogen ingestion in women), alone or combined were identified in our patients. Prevalence of HCV infection was 35.2%. Inherited URO-D deficiency occurs in 25.0% of cases. H63D was the most common hemochromatosis gene mutation. High incidence of PCT associated with HIV infection was found. Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.)Conclusions: PCT is multifactorial. Therefore, knowledge of all risk factors in each patient is important for the management of the disease. ( J Am Acad Dermatol 2005;52:417-24.)
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Mosby-Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject.classification
Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
The role of inherited and acquired factors in the development of porphyria cutanea tarda in the Argentinean population
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-07-26T17:14:57Z
dc.journal.volume
52
dc.journal.number
3 Pt 1
dc.journal.pagination
417-424
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Méndez, Manuel. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Rossetti, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; Argentina
dc.description.fil
Fil: Batlle, Alcira María del C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; Argentina
dc.description.fil
Fil: Parera, Victoria Estela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Investigaciones sobre Porfirinas y Porfirias. Universidad de Buenos Aires. Centro de Investigaciones sobre Porfirinas y Porfirias; Argentina
dc.journal.title
Journal of the American Academy of Dermatology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jaad.2004.09.014
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.jaad.org/article/S0190-9622(04)02489-2/fulltext
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