Artículo
Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities
Fecha de publicación:
06/2021
Editorial:
Molecular Diversity Preservation International
Revista:
Cancers
ISSN:
2072-6694
e-ISSN:
2072-6694
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Chromosomal instability (CIN) refers to an increased rate of acquisition of numerical and structural changes in chromosomes and is considered an enabling characteristic of tumors. Given its role as a facilitator of genomic changes, CIN is increasingly being considered as a possible therapeutic target, raising the question of which variables may convert CIN into an ally instead of an enemy during cancer treatment. This review discusses the origins of structural chromosome abnormalities and the cellular mechanisms that prevent and resolve them, as well as how different CIN phenotypes relate to each other. We discuss the possible fates of cells containing structural CIN, focusing on how a few cell duplication cycles suffice to induce profound CIN-mediated genome alterations. Because such alterations can promote tumor adaptation to treatment, we discuss currently proposed strategies to either avoid CIN or enhance CIN to a level that is no longer compatible with cell survival.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Siri, Sebastian Omar; Martino, Julieta; Gottifredi, Vanesa; Structural chromosome instability: Types, origins, consequences, and therapeutic opportunities; Molecular Diversity Preservation International; Cancers; 13; 12; 6-2021
Compartir
Altmétricas
Items relacionados
Mostrando titulos relacionados por título, autor y tema.
-
Mudry, Marta Dolores ; Rahn, Irene Monica ; Solari, Alberto Juan (Wiley-liss, div John Wiley & Sons Inc., 2001-02)
-
Matturri, Luigi; Cazzullo, Alessandra; Turconi, Paola; Lavezzi, Anna Maria; Vandone, Pier Luigi; Gabrielli, Livio; Fernández Alonso, Graciela; Grana, Daniel Rodolfo ; Milei, Jose (Elsevier Ireland, 2001-02)
-
Poggio, María Georgina ; Provecho, Yael Mariana ; Papeschi, Alba Graciela ; Bressa, Maria Jose (Wiley Blackwell Publishing, Inc, 2013-10)