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dc.contributor.author
Garcés-Villalá, Miguel Ángel
dc.contributor.author
Rico, Sergio David
dc.contributor.author
Nazar, Sergio Gustavo
dc.contributor.author
Escudero-Pinel, Mariano
dc.contributor.author
Galván Josa, Víctor Martín
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dc.contributor.author
Calvo-Guirado, José Luis
dc.date.available
2021-11-24T13:32:02Z
dc.date.issued
2020-07
dc.identifier.citation
Garcés-Villalá, Miguel Ángel; Rico, Sergio David; Nazar, Sergio Gustavo; Escudero-Pinel, Mariano; Galván Josa, Víctor Martín; et al.; Evaluation of two highly porous microcrystalline biphasic calcium phosphate-based bone grafts for bone regeneration: An experimental study in rabbits; Scientific Research Publishing; Journal of Materials Science and Chemical Engineering; 08; 06; 7-2020; 8-30
dc.identifier.issn
2327-6045
dc.identifier.uri
http://hdl.handle.net/11336/147302
dc.description.abstract
A biphasic bone grafting biomaterial based on a mixture of calcium phosphates and beta-tricalcium phosphate (β-TCP) phases with high nanoporosity was synthesized. The synthesis route was based on calcium phosphate composition and the incorporation of glycolic acid as a pore former, giving a material composed of 97% β-TCP and 3% calcium orthophosphates (CaPO4). An in vitro study of the purity, microstructure, crystalline domain, and pores size for the material obtained was performed by SEM analysis as well as full structural characterization. The region of interest related to the surface was determined by the specific surface area measured with the BET method. In vivo evaluation of bone response was performed by implanting the new low-cost biphasic manufacturing material synthesized in this work, which was compared with a biphasic material of similar chemical and microstructural composition existing in the commercial market and with higher cost called Synergy Odontit® β-TCP. The materials were implanted separately into 5 mm diameter defects in the tibias of New Zealand White rabbits at 30, 60, and 90 days. The results obtained showed that the host tissue well accepted the new biphasic material; the presence of new bone formation was observed. A more complete resorption was observed for the new microcrystalline biphasic material compared to for a commercial β-TCP material.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Scientific Research Publishing
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MICROCRYSTALLINE
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BETA-TRICALCIUM PHOSPHATE
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CERAMIC BONE GRAFT
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GLYCOLIC ACID
dc.subject.classification
Biotecnología Industrial
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dc.subject.classification
Biotecnología Industrial
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Evaluation of two highly porous microcrystalline biphasic calcium phosphate-based bone grafts for bone regeneration: An experimental study in rabbits
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-06T16:39:28Z
dc.identifier.eissn
2327-6053
dc.journal.volume
08
dc.journal.number
06
dc.journal.pagination
8-30
dc.journal.pais
China
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dc.description.fil
Fil: Garcés-Villalá, Miguel Ángel. Fundación Corazón de Jesús. Academia de Cirugía Bucal Científica; Argentina
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Fil: Rico, Sergio David. Fundación Corazón de Jesús. Academia de Cirugía Bucal Científica; Argentina
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Fil: Nazar, Sergio Gustavo. Fundación Corazón de Jesús; Department of Implant and Biomaterial Research; San Juan; Argentina
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Fil: Escudero-Pinel, Mariano. Fundación Corazón de Jesús; Department of Implant and Biomaterial Research; San Juan; Argentina
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Fil: Galván Josa, Víctor Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
dc.description.fil
Fil: Calvo-Guirado, José Luis. Universidad Católica San Antonio de Murcia; España
dc.journal.title
Journal of Materials Science and Chemical Engineering
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.scirp.org/journal/doi.aspx?doi=10.4236/msce.2020.86002
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4236/msce.2020.86002
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