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dc.contributor.author
Gatica, Laura Virginia
dc.contributor.author
Oliveros, Liliana B.
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Pérez Diaz, Matias Federico Francisco
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Domínguez, Nora S.
dc.contributor.author
Fornes, Miguel Walter
dc.contributor.author
Gimenez, Maria Sofia
dc.date.available
2017-04-03T19:38:03Z
dc.date.issued
2011-04
dc.identifier.citation
Gatica, Laura Virginia; Oliveros, Liliana B.; Pérez Diaz, Matias Federico Francisco; Domínguez, Nora S.; Fornes, Miguel Walter; et al.; Implication of vitamin a deficiency on vascular injury related to inflammation and oxidative stress: effects on the ultrastructure of rat aorta; Springer Verlag Berlín; European Journal Of Nutrition; 51; 1; 4-2011; 97-106
dc.identifier.issn
1436-6207
dc.identifier.uri
http://hdl.handle.net/11336/14723
dc.description.abstract
Background: Vitamin A deficiency induces activation of NF-kB and impairs activities of antioxidant enzymes in aorta. Aim of the study: We study the effect of vitamin A deficiency on the aorta histoarchitecture and the possibly contribution of its prooxidant and inflammatory effects to artery alterations. Methods: Twenty-one-day-old Wistar male rats were fed during 3 months with vitamin A-deficient diet (−A, n = 8) or the same diet containing 8 mg of retinol palmitate/kg of diet (+A, control, n = 8). In aortas, thiobarbituric reactive substances and reduced glutathione levels were measured by spectrophotometry. Expressions of TNF-alpha, NOX-2, VCAM-1, and TGF-beta1 were assessed by RT–PCR and Western Blot. The morphology of aorta was examined by light and transmission electron microscopy. Results: In −A rats, high levels of TBARS in serum and aorta and low levels of GSH in aorta were found. An increased expression of TNF-alpha, NOX-2, VCAM-1, and TGF-beta1 in aorta from −A rats was observed. Examination of the intimal layer by light microscopy indicated the presence of an irregular surface in −A aortas. TEM studies showed large vacuoles and multivesicular bodies along the endothelium and also multivesicular bodies in the subendothelial space of aortas from −A rats. Furthermore, the histological appearance of internal elastic lamina was different from control. Small vesicles in the medial layer were observed in aortas from vitamin A-deficient rats. Conclusions: Vitamin A deficiency produces histoarchitectural alterations in aorta, which can be associated, at least in part, to the oxidative stress and inflammation induced by vitamin A deficiency.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Verlag Berlín
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Vitamin A
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Aorta Histoarchitecture
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Aterosclerosis
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Tnf-Alpha
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Nox-2
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Vcam-1
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Tgf-Beta1
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Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Implication of vitamin a deficiency on vascular injury related to inflammation and oxidative stress: effects on the ultrastructure of rat aorta
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-30T18:23:57Z
dc.identifier.eissn
1436-6215
dc.journal.volume
51
dc.journal.number
1
dc.journal.pagination
97-106
dc.journal.pais
Alemania
dc.journal.ciudad
Berlín
dc.description.fil
Fil: Gatica, Laura Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina
dc.description.fil
Fil: Oliveros, Liliana B.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina
dc.description.fil
Fil: Pérez Diaz, Matias Federico Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina
dc.description.fil
Fil: Domínguez, Nora S.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina
dc.description.fil
Fil: Fornes, Miguel Walter. Consejo Nacional de Investigaciones Científicas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "Dr. M. Burgos"; Argentina
dc.description.fil
Fil: Gimenez, Maria Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina
dc.journal.title
European Journal Of Nutrition
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00394-011-0198-z
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00394-011-0198-z
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