Artículo
Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue
Mac Keon, Soledad
; Gazzaniga, Silvina Noemí
; Mallerman, Julieta
; Bravo, Alicia Inés; Mordoh, Jose
; Wainstok, Rosa
Fecha de publicación:
11/2010
Editorial:
Elsevier
Revista:
Vaccine
e-ISSN:
1873-2518
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Antigen presentation by dendritic cells (DC) is of key importance for the initiation of the primary immune response. Mice vaccinated with DC charged with apoptotic/necrotic B16 cells (DC-Apo/Nec) are protected against B16 challenge. The aim of this study was to assess vaccine cell migration in our system and to find out if there is an immunological response taking place at the vaccination site. The formation of a pseudocapsule, peripheral node addresin expression in small venules, and the recruitment of a wide variety of cellular populations, including macrophages, polymorphonuclear lymphocytes, and CD8+ and CD4+ T lymphocytes found in association with DC, evidenced the formation of tertiary lymphoid tissue in the vaccination site in our experimental system.
Palabras clave:
Vaccination
,
Melanoma
,
Dendritic Cell
,
Apoptotic Cell
,
Lymphoid Tissue
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Mac Keon, Soledad; Gazzaniga, Silvina Noemí; Mallerman, Julieta; Bravo, Alicia Inés; Mordoh, Jose; et al.; Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue; Elsevier; Vaccine; 28; 51; 11-2010; 8162-8168
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