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dc.contributor.author
Xu, Hao
dc.contributor.author
Agalioti, Theodora
dc.contributor.author
Zhao, Jun
dc.contributor.author
Steglich, Babett
dc.contributor.author
Wahib, Ramez
dc.contributor.author
Amezcua Vesely, Maria Carolina
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dc.contributor.author
Bielecki, Piotr
dc.contributor.author
Bailis, Will
dc.contributor.author
Jackson, Ruaidhri
dc.contributor.author
Perez, Daniel
dc.contributor.author
Izbicki, Jakob
dc.contributor.author
Licona-Limón, Paula
dc.contributor.author
Kaartinen, Vesa
dc.contributor.author
Geginat, Jens
dc.contributor.author
Esplugues, Enric
dc.contributor.author
Tolosa, Eva
dc.contributor.author
Huber, Samuel
dc.contributor.author
Flavell, Richard A.
dc.contributor.author
Gagliani, Nicola
dc.date.available
2021-11-16T14:45:36Z
dc.date.issued
2020-12
dc.identifier.citation
Xu, Hao; Agalioti, Theodora; Zhao, Jun; Steglich, Babett; Wahib, Ramez; et al.; The induction and function of the anti-inflammatory fate of TH17 cells; Nature; Nature Communications; 11; 1; 12-2020; 1-13
dc.identifier.issn
2041-1723
dc.identifier.uri
http://hdl.handle.net/11336/146971
dc.description.abstract
TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cells to acquire an anti-inflammatory fate is necessary to sustain immunological tolerance, yet it impairs immune protection against S. aureus. Additionally, we find that TGF-β signalling via Smad3/Smad4 is sufficient for the expression of the anti-inflammatory cytokine, IL-10, in TH17 cells. Our data thus indicate a key function of TH17 cell plasticity in maintaining immune homeostasis, and dissect the molecular mechanisms explaining the functional flexibility of TH17 cells with regard to environmental changes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
TGFb
dc.subject
Th17
dc.subject
Smad
dc.subject
Plasticity
dc.subject.classification
Otros Tópicos Biológicos
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
The induction and function of the anti-inflammatory fate of TH17 cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-06T15:09:07Z
dc.journal.volume
11
dc.journal.number
1
dc.journal.pagination
1-13
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Xu, Hao. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Agalioti, Theodora. University Medical Center Hamburg-Eppendorf; Alemania
dc.description.fil
Fil: Zhao, Jun. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Steglich, Babett. University Medical Center Hamburg-Eppendorf; Alemania
dc.description.fil
Fil: Wahib, Ramez. University Medical Center Hamburg-Eppendorf; Alemania
dc.description.fil
Fil: Amezcua Vesely, Maria Carolina. University of Yale. School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
dc.description.fil
Fil: Bielecki, Piotr. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Bailis, Will. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Jackson, Ruaidhri. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Perez, Daniel. University Medical Center Hamburg-Eppendorf; Alemania
dc.description.fil
Fil: Izbicki, Jakob. University Medical Center Hamburg-Eppendorf; Alemania
dc.description.fil
Fil: Licona-Limón, Paula. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Kaartinen, Vesa. University Medical Center Hamburg-Eppendorf; Alemania
dc.description.fil
Fil: Geginat, Jens. University Medical Center Hamburg-Eppendorf; Alemania
dc.description.fil
Fil: Esplugues, Enric. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Tolosa, Eva. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Huber, Samuel. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Flavell, Richard A.. University of Yale. School of Medicine; Estados Unidos
dc.description.fil
Fil: Gagliani, Nicola. University Medical Center Hamburg-Eppendorf; Alemania
dc.journal.title
Nature Communications
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41467-020-17097-5
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41467-020-17097-5
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