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dc.contributor.author
Figueroa, R.
dc.contributor.author
Guarda, J.
dc.contributor.author
Leiva, J.
dc.contributor.author
Malano, F.
dc.contributor.author
Valente, Mauro Andres
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dc.date.available
2021-11-12T20:54:08Z
dc.date.issued
2020-10
dc.identifier.citation
Figueroa, R.; Guarda, J.; Leiva, J.; Malano, F.; Valente, Mauro Andres; Dosimetry of tumor targeting imaging by convergent X-ray beam as compared with nuclear medicine; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 167; 10-2020; 1-20
dc.identifier.issn
0969-8043
dc.identifier.uri
http://hdl.handle.net/11336/146827
dc.description.abstract
During decades nuclear medicine procedures, based on radiolabeled agents, have proved to be efficient for diseases diagnosis and treatment. Radiation emerging from patient is detected aimed at localizing radiotracer distribution that is further correlated with biochemical/metabolic physiological processes. However, a significant drawback associated with current nuclear medicine procedures implementing radionuclide infusion regards to the inherent absorbed dose as well as radiopharmaceuticals' production, storage and elimination from patient body, thus representing a risk at patient and public health level. In the recent years, alternative methods have been proposed to reduce/eliminate radionuclides in some nuclear medicine procedures. The combination of high atomic number nanoparticles infused within patient body with incident X-ray beam, like tumor targeting and treatment, appears as a potential alternative method capable of theranostics. The process is based on inducing X-ray fluorescence and secondary electrons emission in high atomic number nanoparticles by means of excitation with an external X-ray beam, avoiding employing radioactive substances. The present work reports on the dosimetry performance of both methods, comparing whenever the external convergent X-ray beam alternative may involve less or larger radiation dose levels, according to comparable signal/image quality during the procedure. To this aim, a simplified theoretical model is proposed and associated Monte Carlo simulations are performed in order to compare typical case of nuclear medicine imaging with potential performance of an innovative method, called OXIRIS (Orthovoltage X-ray Induced Radiation and Integrated System), based on convergent X-ray beam exciting high atomic number nanoparticles infused in patient. The obtained results support the proposed alternative method's feasibility, once demonstrated that patient absorbed dose levels are relative similar to those currently used by nuclear medicine procedures, whereas dose to targeted region (tumor) are significantly higher, which may be useful for treatment purposes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CONVERGENT X-RAY BEAM
dc.subject
GOLD NANOPARTICLE
dc.subject
MONTE CARLO SIMULATIONS
dc.subject
TUMOR TARGETING IMAGING
dc.subject.classification
Otras Ciencias Físicas
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dc.subject.classification
Ciencias Físicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Dosimetry of tumor targeting imaging by convergent X-ray beam as compared with nuclear medicine
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-06T16:43:22Z
dc.journal.volume
167
dc.journal.pagination
1-20
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Figueroa, R.. Universidad de La Frontera; Chile
dc.description.fil
Fil: Guarda, J.. Universidad de La Frontera; Chile
dc.description.fil
Fil: Leiva, J.. Universidad de La Frontera; Chile
dc.description.fil
Fil: Malano, F.. Universidad de La Frontera; Chile
dc.description.fil
Fil: Valente, Mauro Andres. Universidad de La Frontera; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
dc.journal.title
Applied Radiation and Isotopes
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0969804320305959
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.apradiso.2020.109451
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