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dc.contributor.author
Martinez, Nelida Yanina
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dc.contributor.author
Moreno, Mario Sergio Jesus
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dc.date.available
2021-11-12T11:20:00Z
dc.date.issued
2020-02
dc.identifier.citation
Martinez, Nelida Yanina; Moreno, Mario Sergio Jesus; Oil-in-water emulsion development for the encapsulation and sustained release of xanthone; Taylor & Francis; Journal of Dispersion Science and Technology; 41; 3; 2-2020; 355-361
dc.identifier.issn
0193-2691
dc.identifier.uri
http://hdl.handle.net/11336/146774
dc.description.abstract
In the present work, an oil-in-water emulsion was developed for the encapsulation of xanthone, a potent anti-inflammatory and antitumor molecule of natural source. The xanthone is insoluble in water so it was encapsulated for oral administration purposes. Then, nonionic surfactants and bovine serum albumin protein for interface stabilization were used, with a droplet size distribution around 0.2–1 µm. Three initial concentrations of xanthone in the oil droplets were studied (0.142, 0.71 and 1.42 mg/ml), in all cases encapsulation was above 90%. Fourier transformed infrared spectroscopy (FTIR) results showed hydrophilic and hydrophobic interactions between xanthone and the oil droplets. There is a relationship between the initial concentration of xanthone inside the oil droplets and the controlled release. At 1.42 mg/ml, only 1 ± 0.9% and 1.92 ± 0.02% of xanthone was released after 2 hours of incubation in buffer solution pH = 7.1 and pH = 2.2 respectively. At high initial concentration, π-stacking intermolecular interactions preclude the release of xanthone. While at 0.142 mg/ml, 14 ± 1.25% and 10.33 ± 0.1% of xanthone was released at pH = 7.1 and pH = 2.2 respectively. At low initial concentrations of xanthone and neutral pH conditions, the release seems to be mediated by ionic destabilization of the emulsion. In this sense, Na+ ions present in the buffer solution binds to ionized molecules of BSA (pH = 5.4) allocated at the interface of the emulsion. As a consequence, a faster release of xanthone is observed at low initial concentrations at neutral pH than at acidic pH.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
OIL-IN-WATER EMULSION
dc.subject
PH EFFECT
dc.subject
SUSTAINED RELEASE
dc.subject
XANTHONE
dc.subject.classification
Nano-materiales
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dc.subject.classification
Nanotecnología
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Oil-in-water emulsion development for the encapsulation and sustained release of xanthone
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-10-20T18:20:39Z
dc.journal.volume
41
dc.journal.number
3
dc.journal.pagination
355-361
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Martinez, Nelida Yanina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Moreno, Mario Sergio Jesus. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche | Comisión Nacional de Energía Atómica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche; Argentina
dc.journal.title
Journal of Dispersion Science and Technology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1080/01932691.2019.1578663
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/01932691.2019.1578663
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