Mostrar el registro sencillo del ítem
dc.contributor.author
Gladich, Ivan
dc.contributor.author
Berrens, Margaret L.
dc.contributor.author
Rowe, Penny M.
dc.contributor.author
Pereyra, Rodolfo Guillermo
dc.contributor.author
Neshyba, Steven
dc.date.available
2021-11-10T19:24:54Z
dc.date.issued
2020-07
dc.identifier.citation
Gladich, Ivan; Berrens, Margaret L.; Rowe, Penny M.; Pereyra, Rodolfo Guillermo; Neshyba, Steven; Solvation and stabilization of single-strand RNA at the air/ice interface support a primordial RNA world on ice; American Chemical Society; Journal of Physical Chemistry C; 124; 34; 7-2020; 18587-18594
dc.identifier.issn
1932-7447
dc.identifier.uri
http://hdl.handle.net/11336/146613
dc.description.abstract
Outstanding questions about the RNA world hypothesis for the emergence of life on Earth concern the stability and self-replication of prebiotic aqueous RNA. Recent experimental work has suggested that solid substrates and low temperatures could help resolve these issues. Herein, we use classical molecular dynamics simulations to explore the possibility that the substrate is ice itself. Simulations at −20 °C show that an eightnucleotide single strand of RNA, initially situated in the quasi-liquid layer at the air/ice interface, exhibits a robust propensity to reorient itselfits bases turn toward the (hydrophobic) air/ice interface, while its anionic phosphodiester oxygens align with the underlying ice lattice. Kinetic analysis of hydrogen bonding indicates resistance to hydrolysis that is greater than that of an aqueous single-strand RNA at the same temperature. This enhanced resistance, in turn, could increase the opportunities for polymerization and self-copying. These findings thus offer the possibility of a role for an ancient RNA world on ice distinct from that considered in extant elaborations of the RNA world hypothesis. This work is, to the best of our knowledge, the first molecular dynamics study of RNA on ice.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
RNA
dc.subject
MOLECULAR DINAMICS
dc.subject.classification
Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Solvation and stabilization of single-strand RNA at the air/ice interface support a primordial RNA world on ice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-06T16:42:04Z
dc.identifier.eissn
1932-7455
dc.journal.volume
124
dc.journal.number
34
dc.journal.pagination
18587-18594
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Gladich, Ivan. Università degli Studi di Trieste; Italia
dc.description.fil
Fil: Berrens, Margaret L.. United States Department of Energy; Estados Unidos
dc.description.fil
Fil: Rowe, Penny M.. United States Department of Energy; Estados Unidos
dc.description.fil
Fil: Pereyra, Rodolfo Guillermo. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
dc.description.fil
Fil: Neshyba, Steven. United States Department of Energy; Estados Unidos
dc.journal.title
Journal of Physical Chemistry C
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acs.jpcc.0c04273
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acs.jpcc.0c04273
Archivos asociados