Mostrar el registro sencillo del ítem
dc.contributor.author
Bei, Jinlong
dc.contributor.author
Bigi, María Mercedes
dc.contributor.author
Lima, Analía
dc.contributor.author
Zhang, Qi
dc.contributor.author
Blanco, Federico Carlos
dc.contributor.author
Lopez, Beatriz
dc.contributor.author
Yu, Ting
dc.contributor.author
Wang, Zhilin
dc.contributor.author
Dai, Zhangyan
dc.contributor.author
Chen, Zhuang
dc.contributor.author
Cataldi, Angel Adrian
dc.contributor.author
Sasiain, María del Carmen
dc.contributor.author
Ritacco, Gloria Viviana
dc.contributor.author
de la Barrera, Silvia Susana
dc.contributor.author
Soria, Marcelo Abel
dc.contributor.author
Durán, Rosario
dc.contributor.author
Bigi, Fabiana
dc.date.available
2021-11-09T19:48:12Z
dc.date.issued
2020-04-08
dc.identifier.citation
Bei, Jinlong; Bigi, María Mercedes; Lima, Analía; Zhang, Qi; Blanco, Federico Carlos; et al.; A Phenotypic characterization of two isolates of a multidrug resistant outbreak strain of mycobacterium tuberculosis with opposite epidemiological fitness; Hindawi Limited; BioMed Research International; 2020; 8-4-2020; 1-9
dc.identifier.issn
2314-6133
dc.identifier.uri
http://hdl.handle.net/11336/146502
dc.description.abstract
Tuberculosis (TB) is an infectious disease, caused by Mycobacterium tuberculosis, primarily affecting the lungs. The M. tuberculosis strain of the Haarlem family named M was responsible for a large multidrug-resistant TB (MDR-TB) outbreak in Buenos Aires. This outbreak started in the early 1990s and in the mid 2000s still accounted for 29% of all MDR-TB cases in Argentina. By contrast, a clonal variant of strain M, named 410, has caused a single tuberculosis case since the onset of the outbreak. The molecular bases of the high epidemiological fitness of the M strain remain unclear. To assess its unique molecular properties, herein, we performed a comparative protein and lipid analysis of a representative clone of the M strain (Mp) and the nonprosperous M variant 410. We also evaluated their growth in low pH. The variant 410 had higher levels of latency proteins under standard conditions and delayed growth at low pH, suggesting that it is more sensitive to stress stimuli than Mp. Moreover, Mp showed higher levels of mycolic acids covalently attached to the cell wall and lower accumulation of free mycolic acids in the outer layer than the 410 strain. The low expression of latency proteins together with the reduced content of surface mycolic acids may facilitate Mp to evade the host immune responses.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Limited
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Mycobacterium tuberculosis
dc.subject
MDR-TB
dc.subject
DevR
dc.subject
proteomics
dc.subject
mycolic acids
dc.subject
stress
dc.subject.classification
Enfermedades Infecciosas
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
A Phenotypic characterization of two isolates of a multidrug resistant outbreak strain of mycobacterium tuberculosis with opposite epidemiological fitness
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-08-27T20:28:32Z
dc.identifier.eissn
2314-6141
dc.journal.volume
2020
dc.journal.pagination
1-9
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Bei, Jinlong. Guangdong Academy of Agricultural Sciences; China
dc.description.fil
Fil: Bigi, María Mercedes. Universidad de Buenos Aires. Facultad de Agronomía; Argentina
dc.description.fil
Fil: Lima, Analía. Instituto Pasteur de Montevideo; Uruguay
dc.description.fil
Fil: Zhang, Qi. Guangdong Academy of Agricultural Sciences; China
dc.description.fil
Fil: Blanco, Federico Carlos. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Lopez, Beatriz. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
dc.description.fil
Fil: Yu, Ting. Guangdong Academy of Agricultural Sciences; China
dc.description.fil
Fil: Wang, Zhilin. Guangdong Academy of Agricultural Sciences; China
dc.description.fil
Fil: Dai, Zhangyan. Guangdong Academy of Agricultural Sciences; China
dc.description.fil
Fil: Chen, Zhuang. Guangdong Academy of Agricultural Sciences; China
dc.description.fil
Fil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Sasiain, María del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Ritacco, Gloria Viviana. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: de la Barrera, Silvia Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Soria, Marcelo Abel. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Biología Aplicada y Alimentos. Cátedra de Microbiología Agrícola; Argentina
dc.description.fil
Fil: Durán, Rosario. Instituto Pasteur de Montevideo; Uruguay
dc.description.fil
Fil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
BioMed Research International
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/bmri/2020/4741237/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2020/4741237
Archivos asociados