Show simple item record

dc.contributor.author de la Torre, José M.
dc.contributor.author Nogueras, Manuel
dc.contributor.author Borkowski, Eduardo Jorge
dc.contributor.author Suvire, Fernando D.
dc.contributor.author Enriz, Ricardo Daniel
dc.contributor.author Cobo, Justo
dc.date.available 2017-03-31T19:18:55Z
dc.date.issued 2014-04
dc.identifier.citation de la Torre, José M.; Nogueras, Manuel; Borkowski, Eduardo Jorge; Suvire, Fernando D.; Enriz, Ricardo Daniel; et al.; Easy synthesis of new series of pteridine analogs: di- and tetra-hydropyrimido[4,5-d]pyrimidines via 5-pyrimidinecarbaldehydes; Arkat USA; Arkivoc - Archive for Organic Chemistry; 2014; 5; 4-2014; 42-63
dc.identifier.issn 1551-7004
dc.identifier.uri http://hdl.handle.net/11336/14627
dc.description.abstract Pyrimidine-5-carbaldehyde derivatives, of easy access, were selected as precursors for the synthesis of mimic pteridine derivatives 5,6-dihydropyrimido[4,5-d]pyrimidines and 5,6,7,8- tetrahydropyrimido[4,5-d]pyrimidines via 4-amino-(5-aminomethyl)pyrimidine intermediates. Straightforward procedures allow a quick access to these compounds. The dihydro derivatives were prepared means of a final cyclocondensation carried out with orthoesters, catalysed by acid and assisted by microwaves irradiation under solvent free conditions. The final cyclocondensation with carbonyl compounds forming the tetrahydro derivatives was done under mild conditions, in which stereochemical induction was carried out on the building of this skeleton, and stereochemistry assignments corroborated by theoretical calculations.
dc.format application/pdf
dc.language.iso eng
dc.publisher Arkat USA
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject 4-Amino-5-(aminomethyl)pyrimidines
dc.subject Microwave irradiation; ; ; cyclocondensation;
dc.subject Theoretical calculations
dc.subject Acid catalysis
dc.subject Cyclocondensation
dc.subject Stereoselectivity
dc.subject.classification Química Orgánica
dc.subject.classification Ciencias Químicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Easy synthesis of new series of pteridine analogs: di- and tetra-hydropyrimido[4,5-d]pyrimidines via 5-pyrimidinecarbaldehydes
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2016-11-24T19:23:45Z
dc.identifier.eissn 1551-7012
dc.journal.volume 2014
dc.journal.number 5
dc.journal.pagination 42-63
dc.journal.pais Estados Unidos
dc.journal.ciudad Florida
dc.description.fil Fil: de la Torre, José M.. Universidad de Jaén; España
dc.description.fil Fil: Nogueras, Manuel. Universidad de Jaén; España
dc.description.fil Fil: Borkowski, Eduardo Jorge. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Suvire, Fernando D.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
dc.description.fil Fil: Enriz, Ricardo Daniel. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Cobo, Justo. Universidad de Jaén; España
dc.journal.title Arkivoc - Archive for Organic Chemistry
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://quod.lib.umich.edu/a/ark/5550190.p008.653/1
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.3998/ark.5550190.p008.653


Archivos asociados

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial 2.5 Unported (CC BY-NC 2.5)