Show simple item record Josso, Nathalie Rey, Rodolfo Alberto Picard, Jean Yves 2015-07-23T16:51:58Z 2013-12
dc.identifier.citation Josso, Nathalie; Rey, Rodolfo Alberto; Picard, Jean Yves; Anti-Müllerian Hormone: A Valuable Addition to the Toolbox of the Pediatric Endocrinologist; Hindawi; International Journal of Endocrinology; 2013; 12-2013; 1-12
dc.identifier.issn 1687-8337
dc.description.abstract Anti-Müllerian hormone (AMH), secreted by immature Sertoli cells, provokes the regression of male fetal Müllerian ducts. FSH stimulates AMH production; during puberty, AMH is downregulated by intratesticular testosterone and meiotic germ cells. In boys, AMH determination is useful in the clinical setting. Serum AMH, which is low in infants with congenital central hypogonadism, increases with FSH treatment. AMH is also low in patients with primary hypogonadism, for instance in Down syndrome, from early postnatal life and in Klinefelter syndrome from mid-puberty. In boys with nonpalpable gonads, AMH determination, without the need for a stimulation test, is useful to distinguish between bilaterally abdominal gonads and anorchism. In patients with disorders of sex development (DSD), serum AMH determination helps as a first line test to orientate the etiologic diagnosis: low AMH is indicative of dysgenetic DSD whereas normal AMH is suggestive of androgen synthesis or action defects. Finally, in patients with Persistent Müllerian duct syndrome (PMDS), undetectable serum AMH drives the genetic search to mutations in the AMH gene, whereas normal or high AMH is indicative of an end organ defect due to AMH receptor gene defects.
dc.format application/pdf
dc.language.iso eng
dc.publisher Hindawi
dc.rights info:eu-repo/semantics/openAccess
dc.subject AMH
dc.subject Testis
dc.subject Paediatrics
dc.subject Sertoli
dc.subject.classification Pediatría
dc.subject.classification Medicina Clínica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Anti-Müllerian Hormone: A Valuable Addition to the Toolbox of the Pediatric Endocrinologist
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion 2015-07-22T20:47:51Z
dc.journal.volume 2013
dc.journal.pagination 1-12
dc.journal.pais Estados Unidos
dc.description.fil Fil: Josso, Nathalie. Universidad de París Sur, Francia;
dc.description.fil Fil: Rey, Rodolfo Alberto. Consejo Nacional de Invest.cientif.y Tecnicas. Oficina de Coordinacion Administrativa Pque. Centenario. Centro de Investigaciones Endocrinologicas; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biologia Celular E Histologia. Histologia,citologia y Embriologia I; Argentina;
dc.description.fil Fil: Picard, Jean Yves. Universidad de París Sur, Francia;
dc.journal.title International Journal of Endocrinology

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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)