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dc.contributor.author
Josso, Nathalie
dc.contributor.author
Rey, Rodolfo Alberto
dc.contributor.author
Picard, Jean Yves
dc.date.available
2015-07-23T16:51:58Z
dc.date.issued
2013-12
dc.identifier.citation
Josso, Nathalie; Rey, Rodolfo Alberto; Picard, Jean Yves; Anti-Müllerian Hormone: A Valuable Addition to the Toolbox of the Pediatric Endocrinologist; Hindawi; International Journal of Endocrinology; 2013; 12-2013; 1-12
dc.identifier.issn
1687-8337
dc.identifier.uri
http://hdl.handle.net/11336/1461
dc.description.abstract
Anti-Müllerian hormone (AMH), secreted by immature Sertoli cells, provokes the regression of male fetal Müllerian ducts. FSH stimulates AMH production; during puberty, AMH is downregulated by intratesticular testosterone and meiotic germ cells. In boys, AMH determination is useful in the clinical setting. Serum AMH, which is low in infants with congenital central hypogonadism, increases with FSH treatment. AMH is also low in patients with primary hypogonadism, for instance in Down syndrome, from early postnatal life and in Klinefelter syndrome from mid-puberty. In boys with nonpalpable gonads, AMH determination, without the need for a stimulation test, is useful to distinguish between bilaterally abdominal gonads and anorchism. In patients with disorders of sex development (DSD), serum AMH determination helps as a first line test to orientate the etiologic diagnosis: low AMH is indicative of dysgenetic DSD whereas normal AMH is suggestive of androgen synthesis or action defects. Finally, in patients with Persistent Müllerian duct syndrome (PMDS), undetectable serum AMH drives the genetic search to mutations in the AMH gene, whereas normal or high AMH is indicative of an end organ defect due to AMH receptor gene defects.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Amh
dc.subject
Testis
dc.subject
Paediatrics
dc.subject
Sertoli
dc.subject.classification
Pediatría
dc.subject.classification
Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Anti-Müllerian Hormone: A Valuable Addition to the Toolbox of the Pediatric Endocrinologist
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2015-07-22T20:47:51Z
dc.journal.volume
2013
dc.journal.pagination
1-12
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Josso, Nathalie. Universidad de París Sur, Francia;
dc.description.fil
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Invest.cientif.y Tecnicas. Oficina de Coordinacion Administrativa Pque. Centenario. Centro de Investigaciones Endocrinologicas; Universidad de Buenos Aires. Facultad de Medicina. Departamento de Biologia Celular E Histologia. Cat.de Histologia,citologia y Embriologia I; Argentina;
dc.description.fil
Fil: Picard, Jean Yves. Universidad de París Sur, Francia;
dc.journal.title
International Journal of Endocrinology
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